Development of a biointegrated mandibular reconstruction device consisting titanium fiber mesh

• Project/Area Number: 25463141
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: HIROTA Makoto 横浜市立大学, 医学部, 准教授 (20347305)
• Co-Investigator(Renkei-kenkyūsha): HAYAKAWA Tohru 鶴見大学, 歯学部, 教授 (40172994)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 顎骨再建 / チタン材料 / インプラント / 下顎骨再建

Outline of Final Research Achievements

Extensive jaw bone loss due to surgery such as malignant tumor ablation significantly impairs quality of life. Bone reconstructive surgery and dental implant therapy are effective to improve functions of tooth and jaw bone. The present study demonstrated that development of a reconstruction device of jaw bone made of titanium fiber with a diameter of 20-50 micrometers to less invasively restore those functions. The titanium fiber mesh scaffold with a 87%-porosity showed an excellent compatibility with osteoblast. A thin sub-micron hydroxyapatite (HA) coating on titanium fibers without affecting a three dimensional structure of the scaffold improved bio-compatibility with bone tissue. Mechanical simulation showed HA-coated titanium fiber mesh scaffolds ensured a rapid and strong osseointegration in an extensively resected jaw bone even in a critical-sized and immediately loaded segmental bone defect of the mandible.

Research Products

• [Int'l Joint Research] University of California, Los Angeles(米国)
• [Journal Article] Development of a biointegrated mandibular reconstruction device consisting of bone compatible titanium fiber mesh scaffold. (2016)
  • Author(s): Hirota M, Shima T, Sato I, Ozawa T, Iwai T, Ametani A, Sato M, Noishiki Y, Ogawa T, Hayakawa T, Tohnai I
  • Journal Title: Biomaterials Volume: 75 Pages: 223-236
  • DOI: 10.1016/j.biomaterials.2015.09.034
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] High porous titanium scaffold showed higher compatibility than lower porous beta-tricalcium phosphate scaffolds for regulating human osteoblast and osteoclast differentiation. (2015)
  • Author(s): Makoto Hirota, Tohru Hayakawa, Takaki Shima, Akihiro Ametani, Iwai Tohnai
  • Journal Title: Materials Science and Engineering C Volume: 49 Pages: 623-631
  • DOI: 10.1016/j.msec.2015.01.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Development of mandibular reconstruction device made of titanium fiber scaffold. (2013)
  • Author(s): Makoto Hirota
  • Organizer: 21st International conference on oral and maxillofacial surgery
  • Place of Presentation: Barcelona, Sapin