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Functional modulation of limbic system is involved in the development of Atypical Odontalgia

Research Project

Project/Area Number 25463142
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

Shiiba Shunj  九州歯科大学, 歯学部, 准教授 (20285472)

Co-Investigator(Kenkyū-buntansha) NUNOMAKI Masahito  九州歯科大学, 歯科侵襲制御学分野, 助教 (10341489)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords非定型歯痛 / 大脳辺縁系 / 負の情動ストレス / 自律神経活動 / 前頭前野 / 心電図RR'間隔 / スペクトル解析 / 高次脳機能障害 / 海馬 / 扁桃体 / 情動ストレス / 自律神経反応 / ストレス防御機構 / 慢性疼痛 / 筋筋膜痛 / 交感神経活動 / 自律神経機能 / R-R'間隔スペクトル解析
Outline of Final Research Achievements

The purpose of this study was to define a response of sympathetic nervous activity against an emotional stress in Atypical odontalgia (AO) patients. The subjects were ten Japanese with AO who visited our clinic for pain relief (AO group) . Ten adult volunteers were also set up as a control group. The emotional stress, visual stress which was produced by international affective picture system was loaded. The changes of sympathetic nervous activity were estimated by spectral analysis of heartbeat fluctuation. The spectral components analyzed were low frequency power, high frequency power and L/H. L/H during emotional stress loading was significantly higher in AO group than in control group. There found an acceleration of sympathetic nervous activity induced by an emotional stress deeply involves in manifestation and maintenance of AO.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] 情動ストレスが慢性化した頭頸部筋・筋膜痛患者の交感神経活動に与える影響2016

    • Author(s)
      椎葉俊司 布巻昌仁 左合徹平 原野望 吉田充広 坂本和美 小野賢太郎 北村知昭 鱒見進一
    • Journal Title

      日本口腔顔面痛学会雑誌

      Volume: 8 Pages: 7-11

    • NAID

      130005153756

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 慢性疼痛と体質2013

    • Author(s)
      椎葉俊司
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 3 Pages: 281-286

    • NAID

      10031183897

    • Related Report
      2013 Research-status Report
  • [Presentation] ケタミンの抗うつ効果の検討2015

    • Author(s)
      長谷川円 椎葉俊司 左合徹平 多田幸代 中津由博 山口喜一郎 長行事由貴 原野望 布巻昌仁 渡邉誠之
    • Organizer
      第42回日本歯科麻酔学会学術大会
    • Place of Presentation
      日本歯科大学新潟生命歯学部
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ケタミンの抗うつ効果2014

    • Author(s)
      長谷川 円 椎葉 俊司 左合 徹平 多田 幸代 中津 由博 山口 喜一郎 長行事 由貴 原野 望 布巻 昌仁 渡邉 誠之
    • Organizer
      第42回日本歯科麻酔学会
    • Place of Presentation
      日本歯科大学新潟生命歯学部
    • Year and Date
      2014-10-11 – 2014-10-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 筋•筋膜痛患者の自律神経活動2014

    • Author(s)
      椎葉俊司 左合徹平 布巻昌仁 原野 望 鬼頭慎司 小田昌史  松本 忍田中達朗 森本泰宏 渡邉誠之
    • Organizer
      第27回口腔診断学会
    • Place of Presentation
      九州大学百年行動
    • Year and Date
      2014-09-19 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 筋•筋膜痛症患者の自律神経反射2013

    • Author(s)
      椎葉俊司
    • Organizer
      九州歯科学会
    • Place of Presentation
      九州歯科大学講堂
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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