Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection.
| Project/Area Number |
25463151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Kouichi 日本大学, 歯学部, 教授 (60160115)
SHINODA Masamichi 日本大学, 歯学部, 准教授 (20362238)
IMAMURA Yoshiki 日本大学, 歯学部, 教授 (90176503)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経障害性疼痛 / GABA / KCC2 / 三叉神経障害 / 脊髄路核 / 神経科学 / 歯学 / 生理学 / 脳・神経 / シグナル伝達 / 下歯槽神経 / GABA介在神経細胞 / VGAT-Venusラット |
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| Outline of Final Research Achievements |
Involvement of the functional changes in the GABAergic system in the trigeminal spinal subnucleus caudalis (Vc) in the mechanisms underlying extraterritorial neuropathic pain in the orofacial region following inferior alveolar nerve transection (IANX) is investigated. It was revealed that GABAergic Vc neurons might be reduced in their number at the early period after IANX and the functional changes might occur in GABAergic neurons from inhibitory to excitatory at the late period after IANX, suggesting that the neuroplastic changes occur in the GABAergic neuronal network in the Vc due to morphological and functional changes at different time periods following IANX and resulting in the extraterritorial neuropathic pain in the orofacial region following trigeminal nerve injury.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue2016
Author(s)
Nakaya Y, Tsuboi Y, Okada-Ogawa A, Shinoda M, Kubo A, Chen Jui-Y, Noma N, Batbold D, Imamura Y, Sessle BJ, Iwata K.
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Journal Title
Mol Pain
Volume: in press
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Involvement of trigeminal transition zone and laminated subnucleus caudalis in masseter muscle hypersensitivity associated with tooth inflammation.2014
Author(s)
Shimizu K, Matsumoto K, Noma N, Matsuura S, Ohara K, Komiya H, Watase T, Ogiso B, Tsuboi Y, Shinoda M, Hatori K, Nakaya Y, Iwata K.
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] predict the success of local anesthetic block after initial treatment by the carbamazepine?2014
Author(s)
Shiiba S, Tanaka T, Sakamoto E, Oda M, Kito S, Ono K, Wakasugi-Sato N, Matsumoto-Takeda S, Seta Y, Imamura Y, Nakanishi O, Inenaga K, Morimoto Y
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Journal Title
Oral Surg Oral Med Oral Pathol Oral Radiol
Volume: 117
Issue: 1
Pages: 15-21
DOI
Related Report
Peer Reviewed / Open Access
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