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Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection.

Research Project

Project/Area Number 25463151
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

OKADA-OGAWA Akiko  日本大学, 歯学部, 准教授 (10434078)

Co-Investigator(Kenkyū-buntansha) IWATA Kouichi  日本大学, 歯学部, 教授 (60160115)
SHINODA Masamichi  日本大学, 歯学部, 准教授 (20362238)
IMAMURA Yoshiki  日本大学, 歯学部, 教授 (90176503)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords神経障害性疼痛 / GABA / KCC2 / 三叉神経障害 / 脊髄路核 / 神経科学 / 歯学 / 生理学 / 脳・神経 / シグナル伝達 / 下歯槽神経 / GABA介在神経細胞 / VGAT-Venusラット
Outline of Final Research Achievements

Involvement of the functional changes in the GABAergic system in the trigeminal spinal subnucleus caudalis (Vc) in the mechanisms underlying extraterritorial neuropathic pain in the orofacial region following inferior alveolar nerve transection (IANX) is investigated. It was revealed that GABAergic Vc neurons might be reduced in their number at the early period after IANX and the functional changes might occur in GABAergic neurons from inhibitory to excitatory at the late period after IANX, suggesting that the neuroplastic changes occur in the GABAergic neuronal network in the Vc due to morphological and functional changes at different time periods following IANX and resulting in the extraterritorial neuropathic pain in the orofacial region following trigeminal nerve injury.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (29 results)

All 2016 2015 2014 2013 2011 Other

All Journal Article (21 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 20 results,  Open Access: 12 results,  Acknowledgement Compliant: 4 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (5 results)

  • [Journal Article] ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue2016

    • Author(s)
      Nakaya Y, Tsuboi Y, Okada-Ogawa A, Shinoda M, Kubo A, Chen Jui-Y, Noma N, Batbold D, Imamura Y, Sessle BJ, Iwata K.
    • Journal Title

      Mol Pain

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Connexin 43 contributes to ectopic orofacial pain following inferior alveolar nerve injury.2016

    • Author(s)
      Kaji K, Shinoda M, Honda K, Unno S, Shimizu N, Iwata K.
    • Journal Title

      Mol Pain.

      Volume: 8 Pages: 12-12

    • DOI

      10.1177/1744806916633704

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of transient receptor potential vanilloid 1 expression in trigeminal ganglion neurons via methyl-CpG binding protein 2 signaling contributes tongue heat sensitivity and inflammatory hyperalgesia in mice.2016

    • Author(s)
      Suzuki A, Shinoda M, Honda K, Shirakawa T, Iwata K
    • Journal Title

      Molecular Pain

      Volume: 12 Pages: 1-11

    • DOI

      10.1177/1744806916633206

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recent advances in basic research on the trigeminal ganglion.2016

    • Author(s)
      Goto T, Oh SB, Takeda M, Shinoda M, Sato T, Gunjikake KK, Iwata K.
    • Journal Title

      J Physiol Sci.

      Volume: 29

    • NAID

      40020922519

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection.2015

    • Author(s)
      Okada-Ogawa A, Nakaya Y, Imamura Y, Kobayashi M, Shinoda M, Kita K, Sessle BJ, Iwata K.
    • Journal Title

      Experimental of Neurology

      Volume: 28 Pages: 42-52

    • DOI

      10.1016/j.expneurol.2015.02.030

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 舌痛症(バーニングマウス症候群; BMS)の診断と最近の治療方法―舌がヒリヒリ痛む患者さんが来院したら―2015

    • Author(s)
      岡田明子
    • Journal Title

      東京都歯科医師会雑誌

      Volume: 63 Pages: 3-8

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome.2015

    • Author(s)
      Shinoda M, Takeda M, Honda K, Maruno M, Katagiri A, Satoh-Kuriwada S, Shoji N, Tsuchiya M, Iwata K.
    • Journal Title

      Pain

      Volume: 156 Pages: 2528-2537

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p38 phosphorylation in medullary microglia mediates ectopic orofacial inflammatory pain in rats.2015

    • Author(s)
      Kiyomoto M, Shinoda M, Honda K, Nakaya Y, Dezawa K, Katagiri A, Kamakura S, Inoue T, Iwata K.
    • Journal Title

      Mol Pain.

      Volume: 12 Pages: 48-48

    • DOI

      10.1186/s12990-015-0053-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of TRPV1 and TRPA1 in incisional intraoral and extraoral pain.2015

    • Author(s)
      Urata K, Shinoda M, Honda K, Lee J, Maruno M, Ito R, Gionhaku N, Iwata K.
    • Journal Title

      J Dent Res.

      Volume: 94 Issue: 3 Pages: 446-54

    • DOI

      10.1177/0022034514565645

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological and functional changes in regenerated primary afferent fibres following mental and inferior alveolar nerve transection2014

    • Author(s)
      Tsuboi Y, Honda K, Bae YC, Shinoda M, Kondo M, Katagiri A, Echizenya S, Kamakura S, Lee J, Iwata K.
    • Journal Title

      Eur J Pain

      Volume: - Issue: 9 Pages: 1258-1266

    • DOI

      10.1002/ejp.650

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPA1 contributes to capsaicin-induced facial cold hyperalgesia in rats.2014

    • Author(s)
      Honda K, Shinoda M, Furukawa A, Kita K, Noma N, Iwata K.
    • Journal Title

      Eur J Oral Sci.

      Volume: 122 Issue: 6 Pages: 391-6

    • DOI

      10.1111/eos.12157

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of trigeminal transition zone and laminated subnucleus caudalis in masseter muscle hypersensitivity associated with tooth inflammation.2014

    • Author(s)
      Shimizu K, Matsumoto K, Noma N, Matsuura S, Ohara K, Komiya H, Watase T, Ogiso B, Tsuboi Y, Shinoda M, Hatori K, Nakaya Y, Iwata K.
    • Journal Title

      PLoS One.

      Volume: 9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of astroglial glutamate-glutamine shuttle in modulation of the jaw-opening reflex following infraorbital nerve injury.2014

    • Author(s)
      Mostafeezur RM, Shinoda M, Unno S, Zakir HM, Takatsuji H, Takahashi K, Yamada Y, Yamamura K, Iwata K, Kitagawa J.
    • Journal Title

      Eur J Neurosci.

      Volume: inpress Issue: 12 Pages: 2050-2059

    • DOI

      10.1111/ejn.12562

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immune and Endocrine Function in Patients with Burning Mouth Syndrome.2014

    • Author(s)
      Koike K., Shinozaki T., Hara K., Noma N., Okada- Ogawa A., Asano M., Shinoda M., Eliav E., Gracely RH., Iwata K. and Imamura Y
    • Journal Title

      Clin J Pain

      Volume: 30 Issue: 2 Pages: 168-173

    • DOI

      10.1097/ajp.0b013e31828c4bf1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] predict the success of local anesthetic block after initial treatment by the carbamazepine?2014

    • Author(s)
      Shiiba S, Tanaka T, Sakamoto E, Oda M, Kito S, Ono K, Wakasugi-Sato N, Matsumoto-Takeda S, Seta Y, Imamura Y, Nakanishi O, Inenaga K, Morimoto Y
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol

      Volume: 117 Issue: 1 Pages: 15-21

    • DOI

      10.1016/j.oooo.2012.03.029

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of distortion correction on diffusion imaging: comparison of FSL eddy and eddy_correct using 30 and 60 directions diffusion encoding.2014

    • Author(s)
      Yamada H, Abe O, Shizukuishi T, Kikuta J, Shinozaki T, Dezawa K, Nagano A, Matsuda M, Haradome H, Imamura Y.
    • Journal Title

      PLoS One.

      Volume: 9(11) Issue: 11 Pages: e112411-e112411

    • DOI

      10.1371/journal.pone.0112411

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ラット下歯槽神経切断による神経障害性疼痛に対するGABA介在神経細胞の関与2013

    • Author(s)
      岡田明子、鈴木郁子、中谷有香、小林真之、鰻原賀子、今村佳樹、岩田幸一
    • Journal Title

      Pain research

      Volume: 28 Pages: 33-41

    • NAID

      10031165774

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fractalkine signaling in microglia contributes to ectopic orofacial pain following trapezius muscle inflammation.2013

    • Author(s)
      Kiyomoto M, Shinoda M, Okada-Ogawa A, Noma N, Shibuta K, Tsuboi Y, Sessle BJ, Imamura Y, Iwata K
    • Journal Title

      J Neurosci

      Volume: 33 Issue: 18 Pages: 7667-80

    • DOI

      10.1523/jneurosci.4968-12.2013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interaction of IL-1β and P2X3 receptor in pathologic masseter muscle pain.2013

    • Author(s)
      Noma N, Shinoda M, Honda K, Kiyomoto M, Dezawa K, Nakaya Y, Komiyama O, Imamura Y, Iwata K
    • Journal Title

      J Dent Res,

      Volume: 92 Issue: 5 Pages: 456-460

    • DOI

      10.1177/0022034513483770

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative Evaluation of Eating Oral Function in Peripheral Facial Palsy2013

    • Author(s)
      Kato Y, et al.
    • Journal Title

      Clinical Otolaryngology

      Volume: 未定 Issue: 3 Pages: 231-236

    • DOI

      10.1111/coa.12118

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of ERK phosphorylation of trigeminal spinalsubnucleus caudalis neurons in thermal hypersensitivity in rats with infraorbital nerve injury.2011

    • Author(s)
      Suzuki I, Honda K (他10名)
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 2 Pages: e57278-e57278

    • DOI

      10.1371/journal.pone.0057278

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Studying the neural mechanisms of burning mouth syndrome.2015

    • Author(s)
      Okada-Ogawa A
    • Organizer
      15th scientific meeting of AACMD
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 下垂体腫瘍により口腔顔面痛を引き起こした症例2015

    • Author(s)
      岡田明子
    • Organizer
      第19回口腔顔面神経機能学会学術大会
    • Place of Presentation
      日本大学歯学部(東京)
    • Year and Date
      2015-03-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 舌痛症に対する治療戦略

    • Author(s)
      岡田明子
    • Organizer
      日本レーザー治療学会
    • Place of Presentation
      ステーションコンファレンス万世橋(東京)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 痛み診療キーポイント―舌痛症2014

    • Author(s)
      岡田明子、今村佳樹
    • Total Pages
      264
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] 痛みの診療ベストプラクティス 5舌咽神経痛2014

    • Author(s)
      岡田明子, 今村佳樹
    • Total Pages
      159
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Research-status Report
  • [Book] 痛みの診療ベストプラクティス 4舌咽神経痛2014

    • Author(s)
      今村佳樹、岡田明子、野間 昇
    • Total Pages
      159
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Research-status Report
  • [Book] 口腔顔面痛の診断と治療ガイドブック 3局所麻酔薬2013

    • Author(s)
      岡田明子
    • Total Pages
      229
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] 新編顎関節症 4疼痛の基本 疼痛の発生メカニズム2013

    • Author(s)
      岡田明子、今村佳樹
    • Total Pages
      183
    • Publisher
      永末書店
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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