Circulatory dynamics after administration of dexmedetomidine in antipsychotic rats

• Project/Area Number: 25463155
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: Sunada Katsuhisa 日本歯科大学, 生命歯学部, 教授 (50171286)
• Co-Investigator(Kenkyū-buntansha): Tutui Yukako 日本歯科大学, 歯科麻酔学講座, 講師 (20434144)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: デクスメデトミジン / クロルプロマジン / アドレナリン反転 / P-Vカテーテル / 歯科用局所麻酔薬 / 心機能 / 圧容積カテーテル / ラット / 抗精神病薬 / 局所麻酔薬 / 血管収縮薬 / Wistar系ラット

Outline of Final Research Achievements

Concomitant administration of chlorpromazine and adrenaline caused decreases in blood pressure. Vasoconstrictor dexmedetomidine (DEX) has a possibility for local anesthetics adjunct alternative as adrenaline. We measured circulatory dynamics of chlorpromazine rat after DEX injection.Blood pressure, end-diastolic volume, and end-systolic pressure increased. Stroke volume,stroke work, and pulse rate decreased. End-systolic elastance was no change.These results suggest that vasoconstriction effect of DEX increased preload and afterload. And DEX does not affect to cardiac function.
DEX has possibility to become safe anesthetic adjuncts for patients taking chlorpromazine.

Research Products

• [Journal Article] Effects of adrenaline on circulatory dynamics and cardiac function in rats administered chlorpromazine (2016)
  • Author(s): Arisa Sakai Katsuhisa Sunada
  • Journal Title: odontology Volume: 印刷中 Issue: 1 Pages: 103-107
  • DOI: 10.1007/s10266-016-0241-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] アドレナリンがクロルプロマジン投与ラットの循環動態と心機能に与える影響について (2015)
  • Author(s): 酒井有沙 砂田勝久
  • Journal Title: 日本歯科麻酔学会雑誌 Volume: 43 Pages: 638644-638644
  • Peer Reviewed
• [Presentation] クロルプロマジン投与ラットの舌にデクスメデトミジンを注射した場合の循環動態と心機能について (2015)
  • Author(s): 酒井有沙 藤森翔子 村田奈保子 砂田勝久
  • Organizer: 第43回日本歯科麻酔学会
  • Place of Presentation: 学術総合センター(東京都千代田区）
  • Year and Date: 2015-10-30
• [Presentation] Circulatory dynamics and cardiac function after administration of dexmedetomidine in chlorpromazine rats (2015)
  • Author(s): Katsuhisa SUNADA
  • Organizer: 2015 IFDAS
  • Place of Presentation: ベルリン（ドイツ）
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] クロルプロマジン投与ラットの舌に投与したアドレナリンが循環動態および心機能に与える影響 (2014)
  • Author(s): 酒井有沙 辻本源太郎 砂田勝久
  • Organizer: 第42回日本歯科麻酔学会
  • Place of Presentation: 日本歯科大学新潟生命歯学部（新潟県新潟市浜浦町）
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] アドレナリンがクロルプロマジン投与ラットの循環動態および心機能に及ぼす影響について
  • Author(s): 酒井有沙、辻本源太郎、山口さやか、砂田勝久
  • Organizer: 第４１回日本歯科麻酔学会学術大会
  • Place of Presentation: 横浜(新横浜国際ホテル）