Effects of repeated immobilization stress in the early postnatal period on central nervous system, especially the hypothalamus in adult rats

• Project/Area Number: 25463160
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: Yoshihara Toshihiro 北海道大学, 歯学研究科(研究院), 准教授 (60261319)
• Co-Investigator(Kenkyū-buntansha): OSHIMA SHOHEI 北海道大学病院, 講師 (00374546) ; KIKUIRI TAKASHI 北海道大学, 歯学研究科, 助教 (10322819) ; TAKASAKI CHIHIRO 北海道大学, 歯学研究科, 助教 (60451449)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 中枢神経 / ストレス / 身体抑制 / ストレス反応 / ラット / HPAaxis / HPA axis

Outline of Final Research Achievements

Effects of repeated restraint stress in the early postnatal period were examined on the growth of the developing rats and responsibility of the HPA axis to the subsequent novel stress in adulthood.
Repeated restraint stress in the early postnatal period induced long-term effects on growth of developing rats and stress responsibility of the HPA axis to the novel stress in adulthood.

Research Products

• [Journal Article] The ventral ascending noradrenergic bundles are involved in the stress response to immobilization (2015)
  • Author(s): Toshihiro Yoshihara, Yasutaka Yawaka
  • Journal Title: Journal of Behavioral and Brain Science Volume: Vol.5 No.3 Issue: 03 Pages: 88-95
  • DOI: 10.4236/jbbs.2015.53008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Restricted daily feeding of liquid meal reduces the motivation of rats to get food (2015)
  • Author(s): Toshihiro Yoshihara, Yasutaka Yawaka
  • Journal Title: Journal of Behavioral and Brain Science Volume: Vol.5 No.4 Issue: 04 Pages: 130-136
  • DOI: 10.4236/jbbs.2015.54013
  • Peer Reviewed / Acknowledgement Compliant