Development of preventive method for BRONJ with acetylsalicylic acid

• Project/Area Number: 25463161
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: YOSHIMURA Yoshitaka 北海道大学, 歯学研究科(研究院), 准教授 (30230816)
• Co-Investigator(Kenkyū-buntansha): KIKUIRI Takashi 北海道大学, 大学院歯学研究科, 助教 (10322819)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 歯学 / ビスホスホネート

Outline of Final Research Achievements

Bisphosphonates-related osteonecrosis of the jaw (BRONJ) is the intractable disease that is osteonecrosis of the jaw in a patient who was receiving or had been exposed to bisphosphonate therapy. However, the mechanisms of BRONJ are not fully understood, and appropriate therapies have yet to be established. The aim of this study was the effect of acetylsalicylic acid (aspirin) on BRONJ. By the analysis of the BRONJ model mouse, an inflammatory reaction was reduced with acetylsalicylic acid. It was suggested that acetylsalicylic acid might reduce a BRONJ symptom.