| Project/Area Number |
25463162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
Oshima Shohei 北海道大学, 大学病院, 講師 (00374546)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUIRI Takashi 北海道大学, 大学院歯学研究科, 助教 (10322819)
TAKASAKI Chihiro 北海道大学, 大学院歯学研究科, 助教 (60451449)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | calcineurin / tooth eruption / suckling / 吸啜 / c-fos / 吸啜反射 / カルシニューリン / 歯の萌出 |
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| Outline of Final Research Achievements |
Calcineurin was expressed in the enamel organ, the dental follicle and the gingival epithelium of mouse during tooth formation. Until Just before tooth eruption, the expression of calcineurin was confirmed in the enamel organ, the dental follicle and the gingival epithelium. Calcineurin expression appear to correlate with tooth eruption.
In the suckling mouse during postnatal development, immunoreactivity of c-fos was detected in the reticular formation near the trigeminal motor nucleus and the principal sensory nucleus of trigeminal nerve . C-fos was also detected in the lateral lemniscus and the inferior colliculus regardless of suckling. After transection of the infraorbital nerve, the expression pattern of the brainstem after suckling did not change.
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