Study of the anti-aging effects of stem cells from human exfoliated deciduous teeth using progeria mice
Project/Area Number |
25463187
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthodontics/Pediatric dentistry
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
HOSHINO Yoshihiro 九州大学, 病院, 医員 (20444797)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 小児歯科 / ヒト脱落乳歯由来幹細胞 / 小児歯科学 / ヒト乳歯由来幹細胞 / 乳歯幹細胞 |
Outline of Final Research Achievements |
The purpose of this study is to investigate the anti-aging effects of stem cells from human exfoliated deciduous teeth (SHED). We succeeded to isolate SHED and are analyzing the mechanism of aging using progeria mice with SHED administration. In addition, we confirmed the increasing of the bone density in osteoporosis mice with SHED administration and are analyzing its detail mechanism.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice.2015
Author(s)
Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T.
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Journal Title
Stem Cell Res Ther
Volume: 6(1)
Issue: 1
Pages: 171-171
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice.2015
Author(s)
Ma L, Aijima R, Hoshino Y, Yamaza H, Tomoda E, Tanaka Y, Sonoda S, Song G, Zhao W, Nonaka K, Shi S, Yamaza T
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Journal Title
Stem Cell Res. Ther.
Volume: 6(1)
Issue: 1
Pages: 182-182
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect2015
Author(s)
Kamohara R, Yamaza H, Tsuchiya T, Komatsu T, Park S, Hayashi H, Chiba T, Mori R, Otabe S, Yamada K, Nagayasu T, Shimokawa I
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Journal Title
Experimental Gerontology
Volume: 64
Pages: 46-54
DOI
NAID
Related Report
Peer Reviewed / Open Access
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