The elucidation of the alveolar bone bone resorption mechanism in the eruption course formation of the tooth

• Project/Area Number: 25463194
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Iwate Medical University (2017); Kyushu Dental College (2013-2016)
• Principal Investigator: MORIKAWA KAZUMASA 岩手医科大学, 歯学部, 教授 (70514686)
• Co-Investigator(Kenkyū-buntansha): 牧 憲司 九州歯科大学, 歯学部, 教授 (60209400)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 破骨細胞 / 歯槽骨 / 骨吸収 / 萌出 / 細胞接着 / IP３R / ポドゾーム / インテグリン / 接着複合体 / ゼストスポンギンC / Adenophostin A / IP3R

Outline of Final Research Achievements

Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are Ca2+ channels that localize to intracellular Ca2+ stores. Analysis of the experimental data strongly suggest IP3R type III may be related to regulation of an actin cytoskeleton in podosomes, actin-rich adhesion structures in osteoclasts and may be associated with the alveolar bone bone resorption.