| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Weinvestigated the Notch and IL -17 expressions in odontoclasts in resorbed roots during experimental tooth movement in vivo.8-week old male Wistar rats were divided into four groups, a heavy force group (50 g), optimal force group (10 g), jiggling force group (compression and tension, repetition; 10g) and a control group. The expression levels ofJagged1,Notch-2, RANKL, IL-6, IL -17 protein in the dental root determined using an immunohistochemical analysis.The immunoreactivity for Jagged1,Notch-2, RANKL, IL-6, IL -17in resorbed roots exposed to the jiggling force were stronger than that in the other groups on day 21. The number of IL-17-positive odontoclasts was significantly increased in the JF group on day 21 compared with the other groups.These results suggest that Jagged1,Notch-2, RANKL, IL-6, IL -17produced from periodontal tissues response to heavy and jiggling forces may induce odontoclastogenesis during orthodontic tooth movement, and may be one of risk factors for ORR.
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