Investigation of mechanizm in orthodontocally root resorption through nothch signalinhg in periodontal ligament cells and Th17cells
| Project/Area Number |
25463200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 矯正歯科 / 歯根膜細胞 / 歯根吸収 / IL-17 / Notch シグナル / 矯正力 / Notchシグナル / Wnt5a / Notch シグナル / RANKL / IL-6 |
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| Outline of Final Research Achievements |
Weinvestigated the Notch and IL -17 expressions in odontoclasts in resorbed roots during experimental tooth movement in vivo.8-week old male Wistar rats were divided into four groups, a heavy force group (50 g), optimal force group (10 g), jiggling force group (compression and tension, repetition; 10g) and a control group. The expression levels ofJagged1,Notch-2, RANKL, IL-6, IL -17 protein in the dental root determined using an immunohistochemical analysis.The immunoreactivity for Jagged1,Notch-2, RANKL, IL-6, IL -17in resorbed roots exposed to the jiggling force were stronger than that in the other groups on day 21. The number of IL-17-positive odontoclasts was significantly increased in the JF group on day 21 compared with the other groups.These results suggest that Jagged1,Notch-2, RANKL, IL-6, IL -17produced from periodontal tissues response to heavy and jiggling forces may induce odontoclastogenesis during orthodontic tooth movement, and may be one of risk factors for ORR.
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Report
(5 results)
Research Products
(40 results)
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[Journal Article] Individual Variations in the Hardness and Elastic Modulus of the Human Cementum2016
Author(s)
Yamaguchi M, Yao-Umezawa E, Tanimoto Y, Shimizu M, Kikuta J, Hikida T, Takahashi-Hikida M, Horihata S, Suzuki K, Kasai K.
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Journal Title
Journal of Hard Tissue Biology
Volume: 25
Issue: 4
Pages: 345-350
DOI
NAID
ISSN
1341-7649, 1880-828X
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Relationship between root resorption and apoptosis in cementum.2017
Author(s)
Yukari Minato, Masaru Yamaguchi, Mami Shimizu, Jun Kikuta, Takuji Hikida, Momoko Hikida,Masaaki Suemitsu, Kayo Kuyama, Kazutaka Kasai.
Organizer
95th International Association for Dental Research
Place of Presentation
San Francisco, Calif., USA
Year and Date
2017-03-22
Related Report
Int'l Joint Research
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[Presentation] Effect of nasal obstruction on the immune system2017
Author(s)
Yoshiki Murakami, Masaru Yamaguchi, Mami Shimizu, Jun Kikuta, Tomonori Sato, Yurie Horigome, Ryoki Kobayashi ,Kazutaka,Kasai.
Organizer
95th International Association for Dental Research
Place of Presentation
San Francisco, Calif., USA
Year and Date
2017-03-22
Related Report
Int'l Joint Research
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