| Project/Area Number |
25463207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
Miyazawa Ken 愛知学院大学, 歯学部, 教授 (60301636)
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| Co-Investigator(Kenkyū-buntansha) |
TABUCHI Masako 愛知学院学院大学, 歯学部, 准教授 (30418925)
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Shigemi 愛知学院大学, 歯学部, 教授 (60142577)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯科矯正学 / 生体吸収性 / オンプラント / 矯正用アンカースクリュー / BMP / CT |
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| Outline of Final Research Achievements |
The purpose of this study is to development new bioabsorbed mesh onplant system for orthodontic anchorage. Firstly, we prepared a full-thickness osteochondral defect in the patellar fossa of rabbits, added a bisphosphonate (BPs) preparation to bovine tooth-derived Demineralized Dentin Matrix (DDM), which has its own osteochondral repair ability, and investigated osteochondral repair ability in the defects. As a result, we suggested that the addition of high-dose BPs inhibits the osteochondral repair ability of DDM. Secondly, the study was to identify the effect of Reveromycin A (RMA) on inhibiting bone resorption in OPG KO mice. Moreover, RMA reduce alveolar bone loss in OPG KO mice.
These data suggested that two unique agents for inhibiting osteoclast activity might increase the bone formation on bioabsorbed mesh onplant system.
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