| Project/Area Number |
25463211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAITO Emiko 北海道大学, 歯学研究科(研究院), 助教 (80374528)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Shigeru 北海道大学, 大学院歯学研究科, 准教授 (70241338)
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| Co-Investigator(Renkei-kenkyūsha) |
SAITO Akira 北海道大学, 大学院歯学研究科, 助教 (20301913)
TAKAHASHI Tomomi 北海道大学, 大学院歯学研究科, 技術専門職員 (50399953)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 水平性骨欠損 / BMP / FGF / EMD / ハニカムコラーゲン / コラーゲン / ハニカム構造 / 歯周組織再生 / 温度感応性ポリマー / ＢＭＰ / ＦＧＦ / ＥＭＤ |
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| Outline of Final Research Achievements |
This study investigated the effect of the combination of BMP, FGF and EMD, and the effect of honeycomb structure of carrier used when the growth factor was implanted with the aim of increase of periodontal regeneration. This study suggested that the collagen having honeycomb structure of an inner diameter of 200-400μm could adjust the induction of the cells depending on the tunnel direction. Additionally, the new bone formation and cementum formation of the double-layer implantation method consisting of both BMP-2-containing carrier and FGF-2-containing carrier or EMD applying were larger than that of the complex implantation method of BMP-2, FGF-2 and EMD and BMP-2 or FGF-2 or EMD only implantation method. The aberrant healing like ankylosis was inhibited, too. From the above results, this study suggested that implantation method of the double-layer using both BMP-2-containing carrier and bFGF-2-containing carrier or EMD applying could enhance periodontal regeneration.
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