The role of IL-10 in the pathogenesis of chronic inflammatory periodontal disease
| Project/Area Number |
25463216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TABETA Koichi 新潟大学, 医歯学系, 助教 (20401763)
ITO Harue 新潟大学, 医歯学系, 助教 (30397145)
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| Research Collaborator |
YAMAZAKI Kazuhisa
YAMADA Hitomi
MATSUDA Yumi
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周炎 / IL-10 / マウス / 抗炎症 |
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| Outline of Final Research Achievements |
The effect of anti-inflammatory cytokine, IL-10, on inhibition of periodontitis was analyzed. Higher level of IL-10 gene expression was observed in human periodontitis tissues compare to gingivitis tissues. Ligature-induced periodontitis mice model demonstrated both gingival inflammation and bone resorption. Intraperitoneal injection of IL-10 but not direct injection of IL-10 into gingiva protected alveolar bone resorption in this mice model. However systemic IL-10 had no effect on inflammatory cytokine level in gingival tissues. Not only periodontal inflammation but also systemic responses may control periodontal bone resorption.
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Report
(4 results)
Research Products
(30 results)
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[Presentation] P．gingivalis induces systemic diseases via dysbiosis of gut microbiota．2014
Author(s)
Arimatsu K, Domon H, Yamada H, Nakajima M, Miyazawa H, Miyauchi S, Nakajima T, Tabeta K, Yamazaki K
Organizer
92nd General session of the IADR
Place of Presentation
ケープタウンインターナショナルコンベンションセンター、Cape Town, South Africa,
Year and Date
2014-06-25 – 2014-06-28
Related Report
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