| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The effect of anti-inflammatory cytokine, IL-10, on inhibition of periodontitis was analyzed. Higher level of IL-10 gene expression was observed in human periodontitis tissues compare to gingivitis tissues. Ligature-induced periodontitis mice model demonstrated both gingival inflammation and bone resorption. Intraperitoneal injection of IL-10 but not direct injection of IL-10 into gingiva protected alveolar bone resorption in this mice model. However systemic IL-10 had no effect on inflammatory cytokine level in gingival tissues. Not only periodontal inflammation but also systemic responses may control periodontal bone resorption.
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