Analysis of Th17 cells migration and activation in periodontally diseased tissues
| Project/Area Number |
25463219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Tadashi 徳島大学, 大学院医歯薬学研究部, 准教授 (00217770)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯周炎 / Th17細胞 / CCL20 / IL-6 / IL-22 / 歯肉線維芽細胞 / 歯根膜由来細胞 / ヒト歯根膜由来細胞 / Th1細胞 / CXCL10 / 歯根膜細胞 / Ｔｈ１７細胞 / ＣＣＬ２０ |
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| Outline of Final Research Achievements |
We examined the effect of IL-6 and IL-22 on CCL20 production from IL-1beta-stimulated human periodontal ligament cells (HPDLC) or human gingival fibroblasts (HGFs) in this study. We found that IL-6 and IL-22 could synergistically increase CCL20 production from IL-1beta-treated HPDLC or HGFs, respectively. Therefore, IL-6 and IL-22 are related to Th17 cells accumulation in periodontally diseased tissues to induce CCL20 production in periodontal resident cells. These results might explain that IL-6 and IL-22 are involved in the destruction of alveolar bone in periodontally diseased tissue.
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Report
(4 results)
Research Products
(22 results)
