Basic research for analysis of occlusal trauma mechanism using in vitro osteoclastogenesis assay
Project/Area Number |
25463220
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
|
Research Institution | Nagasaki University |
Principal Investigator |
UKAI Takashi 長崎大学, 病院(歯学系), 講師 (20295091)
|
Co-Investigator(Kenkyū-buntansha) |
原 宜興 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (60159100)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 咬合性外傷 / 破骨細胞 / TNFα / RANKL / TNFa / RANKL前刺激 / 吸収活性 / osteoclast |
Outline of Final Research Achievements |
RANKL pre-stimulation before stimulation of TNFa can induce active osteoclast formation. We showed the condition of RANKL pre-stimulation for forming of active osteoclasts. In this condition, osteoclast precursors expressed TRAF6. Moreover, blocking of TRAF6 at RANKL pre-stimulation inhibited TNFa inducing active osteoclast formation. These results suggest RANKL pre-stimulation that TRAF6 is activated is important for forming of TNFa inducing active osteoclasts.
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Report
(5 results)
Research Products
(9 results)