| Project/Area Number |
25463222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Sonoki Kazuo 九州歯科大学, 歯学部, 准教授 (50316155)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Hiromasa 九州歯科大学, 歯学部, 教授 (20137326)
HIKITI Hisako 九州歯科大学, 歯学部, 教授 (50292876)
TSUJISAWA Toshiyuki 九州歯科大学, 歯学部口腔保健学科, 准教授 (60265006)
MURAOKA Kousuke 九州歯科大学, 歯学部, 助教 (80382422)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 動脈硬化 / 糖尿病 / 歯周病 / lipopolysaccaride / MCP-1 / Lipopolysaccaride / 血糖 / 臍帯静脈内皮細胞 |
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| Outline of Final Research Achievements |
To investigate the synergetic effect of diabetes mellitus and periodontal disease on atherosclerosis, vascular endothelial cells were incubated with high glucose and lipopolysacaride (LPS). The atherogenic factor, monocyte chemoattractant protein-1 (MCP-1) expression was enhanced with high glucose and LPS than with normal glucose and LPS. In addition, when vitamin C was preincubated before administaration of high glucose and LPS, it suppressed the enhancement of MCP-1 expression due to high glucose and LPS. Therefore, it was suggested that high glucose enhanced the MCP-1 expression by LPS through the oxidative stress.
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