| Project/Area Number |
25463224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Chosa Naoyuki 岩手医科大学, 歯学部, 講師 (80326694)
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| Co-Investigator(Renkei-kenkyūsha) |
Ishisaki Akira 岩手医科大学, 歯学部, 教授 (20356439)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周組織再生 / 炎症抑制 / 炎症性サイトカイン / 炎症性骨吸収 / 間葉系幹細胞 / SCRG1 / 破骨細胞 / 分化 |
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| Outline of Final Research Achievements |
Mesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, MSCs are strong candidates for use in regenerative medicine and cell therapy. Bone marrow-derived MSCs migrated to various tissues including periodontal tissue by chemotaxis, which plays important roles in anti-inflammatory response and tissue repair. We demonstrated that stimulation of inflammatory cytokines, IL-1β, IL-6 and TNF-α, to increase the production and secretion of SDF-1 and MCP-1 in periodontal ligament-derived MSC-like cells. Interestingly, these chemokines specifically increased the migration of bone marrow-derived MSCs, but did not increase that of the periodontal ligament-derived MSC-like cells. In summary, our studies suggested that efficient regenerative medicine could be implemented by effective use of distinct MSCs obtained from various tissues.
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