Elucidating the molecular mechanism of a peptide, SCRG1, derived from mesenchymal stem cells to suppress the osteoclast differentiation.
Project/Area Number |
25463224
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
|
Research Institution | Iwate Medical University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
Chosa Naoyuki 岩手医科大学, 歯学部, 講師 (80326694)
|
Co-Investigator(Renkei-kenkyūsha) |
Ishisaki Akira 岩手医科大学, 歯学部, 教授 (20356439)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 歯周組織再生 / 炎症抑制 / 炎症性サイトカイン / 炎症性骨吸収 / 間葉系幹細胞 / SCRG1 / 破骨細胞 / 分化 |
Outline of Final Research Achievements |
Mesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, MSCs are strong candidates for use in regenerative medicine and cell therapy. Bone marrow-derived MSCs migrated to various tissues including periodontal tissue by chemotaxis, which plays important roles in anti-inflammatory response and tissue repair. We demonstrated that stimulation of inflammatory cytokines, IL-1β, IL-6 and TNF-α, to increase the production and secretion of SDF-1 and MCP-1 in periodontal ligament-derived MSC-like cells. Interestingly, these chemokines specifically increased the migration of bone marrow-derived MSCs, but did not increase that of the periodontal ligament-derived MSC-like cells. In summary, our studies suggested that efficient regenerative medicine could be implemented by effective use of distinct MSCs obtained from various tissues.
|
Report
(4 results)
Research Products
(22 results)
-
[Journal Article] Establishment of mesenchymal stem cell lines derived from the bone marrow of GFP-transgenic mice exhibiting diversity in intracellular TGF-β and BMP signaling.2016
Author(s)
Sawada, S., Chosa, N., Takizawa, N., Yokota, J., Igarashi, Y., Tomoda, K., Kondo, H., Yaegashi, T., and Ishisaki, A.
-
Journal Title
Mol. Med. Rep.
Volume: 13
Issue: 3
Pages: 2023-2031
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
[Journal Article] Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth2015
Author(s)
Akazawa Y., Hasegawa T., Yoshimura Y., Chosa N., Asakawa T., Ueda K., Sugimoto A., Kitamura T., Nakagawa H., Ishisaki A., Iwamoto T.
-
Journal Title
International Journal of Molecular Medicine
Volume: 36
Issue: 2
Pages: 442-448
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Establishment of immortalized mesenchymal stem cells derived from the submandibular glands of tdTomato transgenic mice.2015
Author(s)
Furukawa, S., Kuwajima, Y., Chosa, N., Satoh, K., Ohtsuka, M., Miura, H., Kimura, M., Inoko, H., Ishisaki, A., Fujimura, A., and Miura, H.
-
Journal Title
Exp. Ther. Med.
Volume: 10
Issue: 4
Pages: 1380-1386
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells2014
Author(s)
Naritaka Tamaoki, Kazutoshi Takahashi, Hitomi Aoki, Kazuki Iida, Tomoko Kawaguchi, Daijirou Hatakeyama, Masatoshi Inden, Naoyuki Chosa, Akira Ishisaki, Takahiro Kunisada, Toshiyuki Shibata, Naoki Goshima, Shinya Yamanaka, and Ken-ichi Tezuka
-
Journal Title
Scientific Reports
Volume: なし
Issue: 1
Pages: 7283-7283
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
[Journal Article] Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.2014
Author(s)
Aomatsu, E., Takahashi, N., Sawada, S., Okubo, N., Hasegawa, T., Taira, M., Miura, H., Ishisaki, A., and Chosa, N.
-
Journal Title
Sci. Rep.
Volume: 4
Issue: 1
Pages: 3652-3652
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-