A bacterial non-coding RNAs search and the dynamics in serious periodontal disease
| Project/Area Number |
25463230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 遺伝子 / 細菌 / RNA / ncRNA / 遺伝子発現 / 歯周病 / non-coding RNA / Red complex / 原核生物 / 次世代シークエンス / 発現調節 / NGS / 核酸 / 病原性 |
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| Outline of Final Research Achievements |
In this study, non-coding RNAs in P. gingivalis, T. forsythia, T. denticola related to severe periodontitis and in A. actinomycetemcomitans related to aggressive periodontitis were analyzed and identified comprehensively using a next generation sequencer. As a result, approximately 50-60% of ncRNA in various bacterial ncRNAs predicted in silico had their expressions actually. Also, new ncRNAs were discovered. This study is useful for the elucidation of new transcriptional regulations in pathogenic bacterial genes and for the diagnosis marker in a periodontal disease in the future.
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Report
(4 results)
Research Products
(2 results)
