| Project/Area Number |
25463232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DEYAMA YOSHIAKI 北海道大学, 大学院歯学研究科, 准教授 (80271667)
KANEHIRA TAKASHI 北海道大学, 北海道大学病院, 講師 (90194935)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Toll様受容体5 / フラジェリン / ケモカイン / 歯槽骨 / 骨芽細胞 / TNF-alpha / IL-1beta / Toll like receptor 5 / CX3CL1 / CXCL12 / 辺縁性歯周炎 / Toll-like receptor 5 / CCL2 |
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| Outline of Final Research Achievements |
Flagellin, the ligand of toll like receptor 5, induced expression of CX3CL1 mRNA, CXCL12 mRNA, in a dose-dependent manner on osteoblastic MC3T3-E1(E1) cells. In addition, the combination of flagellin and inflammatory cytokine such as TNF-alpha and IL-1beta, markedly increased gene expression of these chemokines on E1 cells. These results indicate that osteoblasts are one of the main cells which produce these chemokines and may play roles in host defense as well as bone metabolism.
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