| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Oxidative stress is involved in age-related reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative stress, which may aid in inhibiting age-related reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male rats were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The experimental group exhibited lower periodontal oxidative stress at 16 months of age than the control group. Although protein expression of interleukin-1b did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative stress, but not on inflammatory reactions in healthy rats.
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