| Project/Area Number |
25463248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kagawa University |
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Principal Investigator |
OGAWA TAKAAKI 香川大学, 医学部附属病院, 助教 (50325338)
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| Co-Investigator(Kenkyū-buntansha) |
徳田 雅明 香川大学, 医学部, 教授 (10163974)
松井 義郎 香川大学, 医学部, 教授 (10181687)
三宅 実 香川大学, 医学部, 教授 (20239370)
桑原 知巳 (桑原 知己) 香川大学, 医学部, 教授 (60263810)
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| Co-Investigator(Renkei-kenkyūsha) |
IZUMORI Ken 香川大学, 農学部, 名誉教授 (80035998)
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| Research Collaborator |
SAWADA Daijyou 香川大学, 医学部医学科, 大学院生
TADA Jyunko 香川大学, 医学部医学科, 大学院生
KHALEQUE Hasibul 香川大学, 医学部医学科, 大学院生
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Ｄ-タガトース / キシリトール / Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｍｕｔａｎｓ / 口腔内細菌 / ガム / D-タガトース / Streptococcus mutans |
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| Outline of Final Research Achievements |
D-tagatose is the most suitable for selecting rare sugars that are readily soluble in water, sugars with a degree of sweetness of 60% or more, and the effect for resident bacteria in the oral cavity. In vitro, when D-tagatose was added to the culture broth, proliferation against S. mutans such as GS5, acid and insoluble glucan production was markedly inhibited, biofilm formation was inhibited, and glucosyltransferase activity was inhibited. The production of D-tagatose gum was succeeded, and in vivo, used for 4 weeks of clinical trial. No side effects were observed in the subject. No. of oral bacteria, in particuler No. of S. mutans were decreased with the gums. This result was consistent with in vitro results.
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