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Exploration of relevant factors of oral microbiome maturation by using molecular approach

Research Project

Project/Area Number 25463249
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionKyushu University

Principal Investigator

Takeshita Toru  九州大学, 歯学研究科(研究院), 准教授 (50546471)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Yoshihisa  九州大学, 大学院歯学研究院, 教授 (20192403)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords口腔マイクロバイオーム / 16S rRNA / 舌苔 / 細菌 / マイクロバイオーム / 口腔 / 常在フローラ / 次世代シーケンサー / 成熟
Outline of Final Research Achievements

This study revealed that compositional shift in tongue microbiome occurs during two years from birth. In particular, the relative abundances of dominant bacterial genera greatly changed after introduction of baby food (about 200 days from birth) in many of the subjects, implying that diet change would be a trigger of bacterial community succession. Our result would be the important basis for the establishment of a new approach for oral health promotion, which aims to induce healthy oral microbiome.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014 2013

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study.2016

    • Author(s)
      Takeshita T, Kageyama S, Furuta M, Tsuboi H, Takeuchi K, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y.
    • Journal Title

      Science Reorts

      Volume: 6 Issue: 1 Pages: 1-11

    • DOI

      10.1038/srep22164

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 口腔常在微生物叢の構成と健康との関連2016

    • Author(s)
      竹下徹、山下喜久
    • Journal Title

      日本乳酸菌学会誌

      Volume: 27 Pages: 3-9

    • NAID

      130005628246

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acetaldehyde production by major oral microbes2015

    • Author(s)
      Moritani K Takeshita T, Shibata Y, Ninomiya T, Kiyohara Y, Yamashita Y.
    • Journal Title

      Oral Diseases

      Volume: 21 Issue: 6 Pages: 748-754

    • DOI

      10.1111/odi.12341

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 口腔マイクロバイオームと疾患との関連2015

    • Author(s)
      山下喜久、竹下徹
    • Journal Title

      臨床と微生物

      Volume: 42 Pages: 711-715

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 口腔マイクロバイオーム評価の臨床的意義2015

    • Author(s)
      山下喜久、竹下徹
    • Journal Title

      臨床化学

      Volume: 44 Pages: 290-297

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mechanical induction of interleukin-11 regulates osteo/cementoblastic differentiation of human periodontal ligament stem/progenitor cells.2015

    • Author(s)
      Monnouchi S, Maeda H, Yuda A, Hamano S, Wada N, Tomokiyo A, Koori K, Sugii H, Serita S, Akamine A
    • Journal Title

      J Periodontal Res

      Volume: 50 Issue: 8 Pages: 231-239

    • DOI

      10.1111/iej.12361

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dental plaque development on a hydroxyapatite disk in young adults observed by using a barcoded pyrosequencing approach2015

    • Author(s)
      Takeshita T, Yasui M, Shibata Y, Furuta M, Saeki Y, Eshima N, Yamashita Y
    • Journal Title

      Sci. Rep.

      Volume: 5 Pages: 8136-8136

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults2014

    • Author(s)
      Takeshita T, Matsuo K, Furuta M, Shibata Y, Fukami K, Shimazaki Y, Akifusa S, Han DH, Kim HD, Yokoyama T, Ninomiya T, Kiyohara Y, Yamashita Y
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 6990-6990

    • DOI

      10.1038/srep06990

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of the microbiota in carious dentin lesions using 16S rRNA gene sequencing2014

    • Author(s)
      Obata J, Takeshita T, Shibata Y, Yamanaka W, Unemori M, Akamine A, Yamashita Y
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e103712-e103712

    • DOI

      10.1371/journal.pone.0103712

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Supervised machine learning-based classification of oral malodor based on the microbiota in saliva samples.2014

    • Author(s)
      Nakano Y, Takeshita T, Kamio N, Shiota S, Shibata Y, Suzuki N, Yoneda M, Hirofuji T, Yamashita Y.
    • Journal Title

      Artificial Intelligence in Medicine

      Volume: 60 Issue: 2 Pages: 97-101

    • DOI

      10.1016/j.artmed.2013.12.001

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 疾患および健康に関連する口腔常在マイクロバイオームの探索2015

    • Author(s)
      竹下徹
    • Organizer
      日本乳酸菌学会秋季セミナー
    • Place of Presentation
      東京都
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Salivary microbiome and environmental conditions in the oral cavity2015

    • Author(s)
      Takeshita T, Yamashita Y
    • Organizer
      第63回国際歯科研究学会(JADR)
    • Place of Presentation
      福岡
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A Molecular epidemiology study exploring oral microbiome structure associated with human health2015

    • Author(s)
      Takeshita T, Yamashita Y
    • Organizer
      歯科基礎医学会サテライトシンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Bacterial diversity and community types in saliva and oral environment2015

    • Author(s)
      Toru Takeshita, Michiko Furuta, Hidenori Tsuboi, Shinya Kageyama, Yoshihiro Shimazaki, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshihisa Yamashita
    • Organizer
      5th International Human Microbiome Congress
    • Place of Presentation
      Luxembourg
    • Year and Date
      2015-04-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of oral indigenous microbiota in early childhood2014

    • Author(s)
      Takeshita T
    • Organizer
      ISME15
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-08-25 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 乳幼児期における口腔常在フローラの成熟過程2013

    • Author(s)
      竹下徹
    • Organizer
      九州口腔衛生学会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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