Pathophysiological role of resistin on periodontal disease

• Project/Area Number: 25463253
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Nagasaki University
• Principal Investigator: HAYASHIDA Hideaki 長崎大学, 病院(歯学系), 講師 (20238140)
• Co-Investigator(Kenkyū-buntansha): SAITO Toshiyuki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (10170515) ; FURUGEN Reiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (90253674)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: レジスチン / 相互作用 / 歯周病 / 口腔由来細胞 / 受容体 / ヒト口腔由来細胞

Outline of Final Research Achievements

Previous studies have reported that human resistin is associated with periodontal disease and released from neutrophils stimulated by periodontal pathogens. The purpose of this study is to examine the pathophysiological role of resistin on periodontal disease. The results in this study showed recombinant human resistin do not significantly change genes and proteins in human periodontal cells and any specific receptors in human periodontal cells was not identified to interact with human resistin. Further study will be needed to clarify a role of resistin on periodontal disease.

Research Products

• [Journal Article] Porphyromonas gingivalis and Escherichia coli lipopolysaccharide causes resistin release from neutrophils (2012)
  • Author(s): Furugen R, Hayashida H, Saito T
  • Journal Title: Oral Dis Volume: 19 Issue: 5 Pages: 479-483
  • DOI: 10.1111/odi.12027
  • Peer Reviewed