| Project/Area Number |
25463257
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Matsumoto Dental University (2014-2015)
Kyushu Dental College (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Hidefumi 東北大学, 歯学研究科, 准教授 (70412624)
JIMI Eijiro 九州歯科大学, 歯学部, 教授 (40276598)
FUJIWARA Taku 長崎大学, 医歯薬学総合研究科, 教授 (00228975)
SOH Inho 九州歯科大学, 歯学部, 講師 (10285463)
AWANO Shuji 九州歯科大学, 歯学部, 教授 (20301442)
ANSAI Toshihiro 九州歯科大学, 歯学部, 教授 (80244789)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Streptococcus anginosus / 膿瘍 / 硫化水素 / Porphyromonas gingivalis / L-システイン / βC-S lyase |
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| Outline of Final Research Achievements |
In order to clarify the role of hydrogen sulfide on abscess formation, we constructed the hydrogen-sulfide-deficient mutant of Streptococcus anginosus. There were no differences in abscess formation between wild type and mutant. In addition, we constructed the hydrogen-sulfide-deficient mutant of Porphyromonas gingivalis, too. There were significant differences in abscess formation between wild type and mutant.From these results, we concluded the hydrogen-sulfide producing genes of these organisms have quite different roles for abscess formation. These results suggest that the hydrogen sulfide producing genes regulate the other genes and these genes cause the abscess formation in these bacteria. Of these bacteria, the genes regulated by hydrogen sulfide producing gene seem to be quite different.
In conclusion, we found the hydrogen sulfide-producing gene of P. gingivalis plays crucial role for abscess formation, while that of S. anginosus does not effect on abscess formation.
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