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Neural correlates of dental fear in the cerebral response to dental sounds: An fMRI study

Research Project

Project/Area Number 25463266
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

KARIBE HIROYUKI  日本歯科大学, 生命歯学部, 教授 (50234000)

Co-Investigator(Kenkyū-buntansha) 大久保 善朗  日本医科大学, 大学院医学研究科, 大学院教授 (20213663)
舘野 周  日本医科大学, 医学部, 准教授 (50297917)
肥田 道彦  日本医科大学, 医学部, 講師 (60434130)
Co-Investigator(Renkei-kenkyūsha) NAKA KYOKO  日本歯科大学, 生命歯学部, 非常勤講師 (10468770)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords歯科恐怖 / fMRI / 脳機能 / 脳神経メカニズム / 聴覚刺激 / 視覚刺激
Outline of Final Research Achievements

The present study utilized functional magnetic resonance imaging to assess the relationships between cerebral activation in response to auditory stimuli and levels of dental fear and trait anxiety. We found that activation in the left posterior superior temporal gyrus and bilateral precentral gyri positively correlated with dental fear scores in all participants. In contrast, activation in the right middle temporal gyrus, the left inferior frontal gyrus, and the right insula positively correlated with trait anxiety scores in all participants. This difference in activation may indicate some differential level of processing for both types of anxious behaviors.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] 歯科衛生士が大うつ病性障害患者に対して長期にわたり歯科保健指導を行った1例2016

    • Author(s)
      大嶋依子, 大津光寛, 若槻聡子, 岡田智雄, 苅部洋行, 藤田結子, 永島未来, 羽村 章
    • Journal Title

      日本障害者歯科学会雑誌

      Volume: 37(2) Pages: 169-173

    • NAID

      130005268330

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 摂食障害患者のう蝕経験とその発症要因2016

    • Author(s)
      大津光寛, 藤田結子, 苅部洋行, 軍司さおり, 若槻聡子, 羽村 章,一條智康
    • Journal Title

      心身医学

      Volume: 56(11) Pages: 1127-1133

    • NAID

      130005276984

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors affecting the dental erosion severity of patients with eating disorders2014

    • Author(s)
      Otsu M, Hamura A, Ishikawa Y, Karibe H, Ichijyo T, Yoshinaga Y
    • Journal Title

      BioPsychoSocial Medicine

      Volume: 8 Issue: 1 Pages: 25-25

    • DOI

      10.1186/1751-0759-8-25

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Interaction effect of voice-specific function and BDNF Val66Met: An fMRI study2017

    • Author(s)
      Koeda M, Watanabe A, Ikeda Y, Karibe H, Tateno A, Matsuura M, Suzuki H, Okubo Y
    • Organizer
      Organization for Human Brain Mapping
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2017-06-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯科医師に対する信頼度と健康関連QOLとの関連性2017

    • Author(s)
      苅部洋行、加藤雄一
    • Organizer
      日本心身医学会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2017-06-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Relationship between belief in dentists and health-related quality of life2017

    • Author(s)
      Karibe H, Kato Y, Okamoto A.
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural correlates of dental fear and trait anxiety in the cerebral response to dental sounds2016

    • Author(s)
      Karibe H, Koeda M, Tateno A, Kato Y, Okubo Y
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gender Differences in Japanese Adolescents’ Confidence in Dentists2016

    • Author(s)
      Karibe H, Shimazu K, Kato Y
    • Organizer
      American Association for Dental Research
    • Place of Presentation
      Los Angeles Convention Center (Los Angeles, CA, USA)
    • Year and Date
      2016-03-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔内への刺激で生じる嘔吐感の緩和に関する研究2015

    • Author(s)
      柴垣皓一、伊崎安莉奈、大野可珠馬、竹川貴裕、 宮坂直樹、山内優美、加藤雄一、島津貴咲、苅部洋行
    • Organizer
      日本小児歯科学会
    • Place of Presentation
      シェーンバッハ・サボー(東京都千代田区)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Sex differences in affective ratings of dental treatment sounds2015

    • Author(s)
      Karibe H, Kato Y, Aoyagi-Naka K
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 行動療法により歯科治療恐怖症状が顕著に改善した1例2014

    • Author(s)
      永島未来,大津光寛,平林幹貴,石川結子,石井隆資,苅部洋行,羽村章
    • Organizer
      日本障害者歯科学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-11-14 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 人の声に選択的な脳賦活部位に対するCNTNAP2多型の影響:機能的MRI研究2014

    • Author(s)
      肥田道彦,渡辺淳,池田裕美子,キムウーチャン,舘野周,苅部洋行,鈴木秀典,松浦雅人,大久保善朗
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      奈良県文化会館(奈良県奈良市)
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Relationship between belief in dentists and anxiousness2013

    • Author(s)
      Kato Y, Shimazu K, Karibe H
    • Organizer
      International Association of Pediatric Dentistry
    • Place of Presentation
      Coex convention center, Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] 当センターにおける歯科恐怖症例,1年経過後の傾向2013

    • Author(s)
      永島未来、大津光寛、平林幹貴、羽村 章、苅部洋行、岡田智雄、石井隆資、石川結子
    • Organizer
      第30回日本障害者歯科学会
    • Place of Presentation
      兵庫県,神戸国際展示場
    • Related Report
      2013 Research-status Report
  • [Presentation] Brain activity during the presentation of dental treatment sounds: an fMRI study2013

    • Author(s)
      Karibe H, Koeda M, Tateno A,
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego convention center, San Diego, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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