Identification of fluoride transporter that contribute to fluoride resistance in Streptococcus mutans
| Project/Area Number |
25463269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HANADA Nobuhiro 鶴見大学, 歯学部, 教授 (70180916)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Streptococcus mutans / フッ化物 / ミュータンスレンサ球菌 / フッ化物耐性遺伝子 |
|---|
| Outline of Final Research Achievements |
Dental caries is one of the most common infectious diseases in the world. Fluoride application is one of the most effective method for dental caries prevention. The mechanisms of action of fluoride in preventing dental caries are thought to involve the promotion of acid resistance in teeth and tooth remineralization. In addition, fluoride inhibits glycolytic system in bacteria. Therefore, fluoride may also provide antimicrobial activity. It is an epoch-making if fluoride also contributes to the growth inhibition of cariogenic Streptococcus mutans.
To explore the required measures, we identified the genes that resisted fluoride toxicity in Streptococcus mutans.
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Report
(4 results)
Research Products
(6 results)
