A cohort study for identifying risk factors of dental caries and periodontal disease

• Project/Area Number: 25463275
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Ehime University (2014-2015); Fukuoka University (2013)
• Principal Investigator: TANAKA KEIKO 愛媛大学, 医学(系)研究科(研究院), 助教 (40341432)
• Co-Investigator(Kenkyū-buntansha): Miyake Yoshihiro 愛媛大学, 大学院医学系研究科, 教授 (50330246)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 疫学 / コホート研究 / う蝕 / 歯周病 / リスク要因 / 前向きコホート研究 / 齲蝕 / 遺伝子多型 / 若年成人 / 小児

Outline of Final Research Achievements

The Kyushu Okinawa Maternal and Child Health Study (KOMCHS) is an ongoing prospective prebirth cohort study that investigates risk and preventive factors for maternal and child health problems such as oral health and allergic disorders.
Higher maternal vitamin D intake during pregnancy was associated with a lower risk of dental caries in children. Among young women, an inverse association between calcium intake and the prevalence of periodontal disease was observed. The heterozygous variant genotype of the IL1 rs16944 was associated a reduced risk of periodontal disease. No interaction of any of the IL1 polymorphisms with smoking was observed.

Research Products

• [Journal Article] Feeding practices in early life and later intake of fruit and vegetables among Japanese toddlers: the Osaka Maternal and Child Health Study (2016)
  • Author(s): Okubo H, Miyake Y, Tanaka K, Sasaki S, Hirota Y
  • Journal Title: Public Health Nutrition Volume: 19 Issue: 4 Pages: 650-657
  • DOI: 10.1017/s1368980015001779
  • Peer Reviewed
• [Journal Article] Association of prenatal exposure to maternal smoking and postnatal exposure to household smoking with dental caries in 3-year-old Japanese children (2015)
  • Author(s): Tanaka K, Miyake Y, Nagata C, Furukawa S, Arakawa M
  • Journal Title: Environ Res Volume: 143 Pages: 148-153
  • DOI: 10.1016/j.envres.2015.10.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Higher vitamin D intake during pregnancy is associated with reduced risk of dental caries in young Japanese children (2015)
  • Author(s): Tanaka K, Hitsumoto S, Miyake Y, Okubo H, Sasaki S, Miyatake N, Arakawa M
  • Journal Title: Ann Epidemiol Volume: 25 Issue: 8 Pages: 620-5
  • DOI: 10.1016/j.annepidem.2015.03.020
  • Peer Reviewed / Open Access
• [Journal Article] Intake of dairy products and calcium and prevalence of depressive symptoms during pregnancy in Japan: a cross-sectional study. (2015)
  • Author(s): Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M.
  • Journal Title: BJOG. Volume: 122 Issue: 3 Pages: 336-343
  • DOI: 10.1111/1471-0528.12972
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] IL5RA polymorphisms, smoking, and eczema in Japanese women: The Kyushu Okinawa Maternal and Child Health Study. (2015)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: Int J Immunogenet. Volume: 42 Issue: 1 Pages: 52-57
  • DOI: 10.1111/iji.12172
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between TSLP polymorphisms and eczema in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2015)
  • Author(s): Miyake Y, Hitsumoto S, Tanaka K, Arakawa M.
  • Journal Title: Inflammation. Volume: [Epub ahead of print] Issue: 4 Pages: 1663-1668
  • DOI: 10.1007/s10753-015-0143-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Maternal total caffeine intake, mainly from Japanese and Chinese tea, during pregnancy was associated with risk of preterm birth: the Osaka Maternal and Child Health Study (2015)
  • Author(s): Okubo H, Miyake Y, Tanaka K, Sasaki S, Hirota Y
  • Journal Title: Nutr Res Volume: 35 Issue: 4 Pages: 309-316
  • DOI: 10.1016/j.nutres.2015.02.009
  • Peer Reviewed
• [Journal Article] Calcium intake is associated with decreased prevalence of periodontal disease in young Japanese women. (2014)
  • Author(s): Tanaka K, Miyake Y, Okubo H, Hanioka T, Sasaki S, Miyatake N, Arakawa M
  • Journal Title: Nutr J Volume: 13 Issue: 1 Pages: 109-109
  • DOI: 10.1186/1475-2891-13-109
  • NAID: 120006979251
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Seaweed consumption and prevalence of depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study (2014)
  • Author(s): Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M.
  • Journal Title: BMC Pregnancy Childbirth. Volume: 14 Issue: 1 Pages: 301-301
  • DOI: 10.1186/1471-2393-14-301
  • NAID: 120006980635
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Maternal consumption of dairy products, calcium, and vitamin D during pregnancy and infantile allergic disorders. (2014)
  • Author(s): Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M.
  • Journal Title: Ann Allergy Asthma Immunol. Volume: 113 Issue: 1 Pages: 82-87
  • DOI: 10.1016/j.anai.2014.04.023
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between 17q12-21 variants and asthma in Japanese women: rs11650680 polymorphism as potential genetic marker for asthma. (2014)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: DNA Cell Biol. Volume: 33 Issue: 8 Pages: 531-536
  • DOI: 10.1089/dna.2014.2387
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2014)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: Scand J Immunol. Volume: 79 Issue: 6 Pages: 410-414
  • DOI: 10.1111/sji.12171
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationship between IL1 gene polymorphisms and periodontal disease in Japanese women. (2014)
  • Author(s): Tanaka K, Miyake Y, Hanioka T, Arakawa M.
  • Journal Title: DNA Cell Biol. Volume: 33 Issue: 4 Pages: 227-233
  • DOI: 10.1089/dna.2013.2202
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Alcohol consumption during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study. (2014)
  • Author(s): Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M.
  • Journal Title: BMC Pregnancy Childbirth. Volume: 14 Issue: 1 Pages: 79-79
  • DOI: 10.1186/1471-2393-14-79
  • NAID: 120006980636
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Case-control study of rhinoconjunctivitis associated with IL5RA polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2014)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: Cytokine Volume: 65 Issue: 2 Pages: 138-142
  • DOI: 10.1016/j.cyto.2013.11.006
  • Peer Reviewed
• [Journal Article] Low birth weight, preterm birth or small-for-gestational-age are not associated with dental caries in young Japanese children. (2014)
  • Author(s): Tanaka K, Miyake Y.
  • Journal Title: BMC Oral Health. Volume: 14 Issue: 1 Pages: 38-38
  • DOI: 10.1186/1472-6831-14-38
  • Peer Reviewed / Open Access
• [Journal Article] Prognosis of primary aldosteronism in Japan: results from a nationwide epidemiological study. (2014)
  • Author(s): Miyake Y, Tanaka K, Nishikawa T, Naruse M, Takayanagi R, Sasano H, Takeda Y, Shibata H, Sone M, Satoh F, Yamada M, Ueshiba H, Katabami T, Iwasaki Y, Tanaka H, Tanahashi Y, Suzuki S, Hasegawa T, Katsumata N, Tajima T, Yanase T.
  • Journal Title: Endocr J. Volume: 61 Pages: 35-40
  • NAID: 130004443933
  • Peer Reviewed
• [Journal Article] Daily smoking may independently predict caries development in adults (2014)
  • Author(s): Hanioka T, Ojima M, Tanaka K
  • Journal Title: J Evid Based Dent Pract Volume: 14 Issue: 3 Pages: 151-153
  • DOI: 10.1016/j.jebdp.2014.07.005
  • Peer Reviewed / Open Access
• [Journal Article] Dietary patterns in infancy and their associations with maternal socio-economic and lifestyle factors among 758 Japanese mother-child pairs: the Osaka Maternal and Child Health Study. (2013)
  • Author(s): Okubo H, Miyake Y, Sasaki S, Tanaka K, et al.
  • Journal Title: Matern Child Nutr. Volume: in press Issue: 2 Pages: 213-225
  • DOI: 10.1111/j.1740-8709.2012.00403.x
  • Peer Reviewed
• [Journal Article] Infant feeding practices and risk of dental caries in Japan: the Osaka Maternal and Child Health Study (2013)
  • Author(s): Tanaka K, Miyake Y, Sasaki S, Hirota Y
  • Journal Title: Pediatr Dent Volume: 35 Pages: 267-271
  • Peer Reviewed
• [Journal Article] Socioeconomic status and risk of dental caries in Japanese preschool children: the Osaka Maternal and Child Health Study. (2013)
  • Author(s): Tanaka K, Miyake Y, et al.
  • Journal Title: J Public Health Dent. Volume: in press Issue: 3 Pages: 217-223
  • DOI: 10.1111/jphd.12016
  • Peer Reviewed
• [Journal Article] Active and passive smoking and prevalence of periodontal disease in young Japanese women. (2013)
  • Author(s): Tanaka K, Miyake Y, et al.
  • Journal Title: J Periodontal Res. Volume: in press Issue: 5 Pages: 600-5
  • DOI: 10.1111/jre.12044
  • Peer Reviewed
• [Journal Article] VDR gene polymorphisms, interaction with smoking, and risk of periodontal disease in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2013)
  • Author(s): Tanaka K, Miyake Y, Hanioka T, Arakawa M.
  • Journal Title: Scand J Immunol. Volume: 78 Issue: 4 Pages: 371-377
  • DOI: 10.1111/sji.12095
  • Peer Reviewed
• [Journal Article] Salivary cotinine concentrations and prevalence of periodontal disease in young Japanese women: the Kyushu Okinawa Maternal and Child Health Study (2013)
  • Author(s): Tanaka K, Matsuse R. Miyake Y, Hanioka T, Arakawa M
  • Journal Title: Journal of Periodontology Volume: 84 Issue: 12 Pages: 1724-1729
  • DOI: 10.1902/jop.2013.120670
  • Peer Reviewed
• [Journal Article] Case-control study of eczema in relation to IL4Rα genetic polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2013)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: Scand J Immunol. Volume: in press Issue: 5 Pages: 413-418
  • DOI: 10.1111/sji.12043
  • Peer Reviewed
• [Journal Article] Lack of relationship between birth conditions and allergic disorders in Japanese children aged three Years. (2013)
  • Author(s): Miyake Y, Tanaka K.
  • Journal Title: J Asthma. Volume: (印刷中) Issue: 6 Pages: 555-559
  • DOI: 10.3109/02770903.2013.790422
  • Peer Reviewed
• [Journal Article] Active and passive maternal smoking during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study. (2013)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: BMC Pregnancy Childbirth Volume: 13 Pages: 157-157
  • NAID: 120006980641
  • Peer Reviewed
• [Journal Article] Relationship between IL4 polymorphisms and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2013)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: J Investig Allergol Clin Immunol. Volume: 23 Pages: 242-247
  • Peer Reviewed
• [Journal Article] IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2013)
  • Author(s): Miyake Y, Tanaka K, Arakawa M.
  • Journal Title: Cytokine Volume: 64 Issue: 1 Pages: 86-89
  • DOI: 10.1016/j.cyto.2013.07.020
  • Peer Reviewed
• [Journal Article] Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: the Kyushu Okinawa Maternal and Child Health Study. (2013)
  • Author(s): Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M.
  • Journal Title: Ann Epidemiol Volume: 23 Issue: 11 Pages: 674-680
  • DOI: 10.1016/j.annepidem.2013.08.004
  • Peer Reviewed
• [Presentation] IL18遺伝子多型と歯周病との関連：吸収・沖縄母子保健研究 (2015)
  • Author(s): 田中景子、三宅吉博、埴岡隆、宮武伸行、荒川雅志
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-03-28
• [Presentation] Higher vitamin D intake during pregnancy is associated with reduced risk of dental caries in young Japanese children (2015)
  • Author(s): Tanaka K, Miyake Y, Okubo H, Sasaki S, Arakawa M
  • Organizer: 第25回日本疫学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-01-23
• [Presentation] カルシウム摂取と歯周病との関連：九州・沖縄母子保健研究 (2014)
  • Author(s): 田中景子、三宅吉博、大久保公美、埴岡隆、佐々木敏、荒川雅志
  • Organizer: 第63回日本口腔衛生学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2014-05-31
• [Presentation] ＶＤＲ遺伝子多型と歯周病との関連：九州・沖縄母子保健研究 (2013)
  • Author(s): 田中景子、三宅吉博、埴岡隆、荒川雅志
  • Organizer: 第72回日本公衆衛生学会総会
  • Place of Presentation: 三重
• [Remarks] 愛媛大学大学院医学系研究科疫学・予防医学講座 研究成果
  • URL: http://www.m.ehime-u.ac.jp/school/publichealth/works.php