The salivary gland culture system for developing the care of xerostomia.
| Project/Area Number |
25463286
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fundamental nursing
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGAWA Hiroyuki 千葉大学, 理学研究科, 准教授 (40143250)
NOGAWA Hiroyuki 福島県立医科大学, 医学部, 准教授 (80250190)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 唾液分泌低下 / 放射線療法 / がん化学療法 / がん治療の有害事象 / 唾液腺培養系 / 唾液腺体外培養 / 細胞表面マーカー / 唾液腺 / がん治療 / 培養モデル / 放射線治療 |
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| Outline of Final Research Achievements |
Radiotherapy for head and neck cancers and/or chemotherapy can cause salivary gland dysfunction and subsequent xerostomia, leading to poor quality of life (QOL) in cancer survivors. To understand the molecular mechanism of the salivary gland dysfunction and develop a preventive care, we are trying to establish an ex vivo salivary gland culture system. To develop the culture system, we tested the effects of growth factors on cultured epithelia of mouse embryonic submandibular glands. This study showed that it is possible to establish the ex vivo salivary gland culture system which can maintain c-Kit+ cells by adding NRG1 + FGF1 and differentiate into AQP5+ cells by removing FGF1 whenever necessary.
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Report
(4 results)
Research Products
(7 results)
