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Promoted Nursing Care of Wound Healing Based on Mechanisms of The Deep Tissue Injury (DTI)

Research Project

Project/Area Number 25463287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fundamental nursing
Research InstitutionYamagata University

Principal Investigator

MATSUDA YUMI  山形大学, 医学部, 准教授 (90444926)

Co-Investigator(Kenkyū-buntansha) KANNO EMI  東北大学, 大学院医学系研究科, 講師 (10431595)
ISHIDA YOKO  山形大学, 医学部看護学科, 講師 (60322335)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords深部損傷褥瘡 / DTI / 冷罨法 / 温罨法 / 創傷治癒 / HMGB1 / 線維芽細胞 / deep tissue Injury / 皮膚 / 深部損傷褥瘡(DTI) / 圧迫創動物モデル / 褥瘡発生初期 / 看護ケア
Outline of Final Research Achievements

In the present study, we evaluated the effects that cool and hot packs as an initial therapy has contributed wound healing on post-pressure induced deep tissue injury model mouse.
Wound healing is similar to that of secondary intention on the model mouse. The cool group had significant tissue necrosis in the epidermis/dermis, but l though the deep skeletal muscle had been damaged, muscle cell regeneration was noted on days 5 to 7. The hot group exhibited reverse findings in the respective tissue layers, and had delayed regeneration of skeletal muscle. Applied cool or hot packs to the pressure wound were indicated different effects on each layer of the skin tissue including muscles.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] 圧迫による深部組織損傷を伴う慢性創傷動物モデルの作製.2016

    • Author(s)
      松田友美,石田陽子,高橋勇太,片岡ひとみ,武田利明
    • Journal Title

      日本褥瘡学会学誌

      Volume: 18巻(1号) Pages: 7-14

    • NAID

      40020756726

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 刺激性抗がん剤(シクロホスファミド)の血管外漏出に対する罨法の作用に関する実験的研究2014

    • Author(s)
      小髙亜由美,松田友美,石田陽子
    • Journal Title

      日本創傷・オストミー・失禁管理学会誌

      Volume: 18(1) Pages: 29-36

    • NAID

      130008031927

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Histological changes induced by cold/hot packs in pressure-related deep tissue injury mouse model for pressure ulcer2016

    • Author(s)
      Yumi Matsuda, Noriko Bandai, Yoko Ishida, Natsuko Miura, Hitomi Kataoka, Toshiaki Takeda
    • Organizer
      5th CONGRESS OF WORLD UNION OF WOUND HEALING SOCIETES
    • Place of Presentation
      FIRENZE, FORTEZZA DA BASSO, Italy
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 圧迫創モデルマウスにおける罨法が創傷に与える影響―線維芽細胞の分布に着目して―2015

    • Author(s)
      坂大 典子,高橋 勇太,新野 美紀,石田 陽子,松田 友美
    • Organizer
      日本看護技術学会第14回学術集会
    • Place of Presentation
      ひめぎんホール(愛媛県愛媛市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス圧迫創におけるHMGB1陽性細胞分布の特徴2014

    • Author(s)
      松田友美,高橋勇太,菅野恵美,石田陽子
    • Organizer
      実験動物セミナー第25回研究成果発表会
    • Place of Presentation
      山形大学医学部医学交流会館(山形)
    • Year and Date
      2014-12-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 圧迫創モデルマウスにおける罨法が創傷に与える影響―線維芽細胞の分布に着目して―2014

    • Author(s)
      坂大典子,新野美紀,加賀紀子,松田友美
    • Organizer
      第4回Co-Medical研究会
    • Place of Presentation
      山形大学医学部看護学科(山形)
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス圧迫創におけるHMGB1陽性細胞の経時的変化2013

    • Author(s)
      松田友美
    • Organizer
      第43回日本創傷治癒学会
    • Place of Presentation
      別府湾ロイヤルホテル(大分県速見郡)
    • Related Report
      2013 Research-status Report
  • [Book] 図解ワンポイント解剖学 人体の構造と機能2016

    • Author(s)
      松田友美,石田陽子,渡辺皓他
    • Total Pages
      231
    • Publisher
      サイオ出版
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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