| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
To reveal the functional meanings of DNA methylation in Neurospora crassa, a series of comparative analyses was performed among wild type and three mutants with deficient or showing altered DNA methylation. By using whole-genome bisulfite sequencing (WGBS) and chromatin immunoprecipitation combined with massive parallel sequencing (ChIP-Seq), genome-wide states for DNA methylation and histone post-translational modification were compared. We observed some interesting relationships between histone modifications and DNA methylation, which indicates the existence of novel function of DNA methylation on histone modifications.
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