| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we tried to address how Polycomb repressive complex 1 (PRC1) suppresses its target genes via RNA molecule(s). We performed the RNA immuno-precipitation (RIP) assay using the antibody against Ring1B protein that is a catalytic subunit of PRC1, and discovered (1) PRC1 (Ring1B) binds to Xist RNA and mRNAs that code components of PRC1 itelf, and (2) the binding between PRC1 and these RNAs is not mediated by Ring1B or Cbx proteins but an unknown 120 kDa protein.
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