Pathophysiological significance of fatty acid composition and catalytic enzyme in pulmonary diseases.

• Project/Area Number: 25504002
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Gunma University
• Principal Investigator: MATSUI HIROKI 群馬大学, 保健学研究科, 講師 (20431710)
• Co-Investigator(Kenkyū-buntansha): YOKOYAMA TOMOYUKI 群馬大学, 大学院保健学研究科, 教授 (70312890)
• Co-Investigator(Renkei-kenkyūsha): KURABAYASHI MASAHIKO 群馬大学, 大学院医学系研究科, 教授 (00215047)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脂肪酸分画 / 触媒酵素 / 肺線維症 / 肺気腫 / 酵素 / 飽和脂肪酸 / 不飽和脂肪酸 / 肺サーファクタント

Outline of Final Research Achievements

The alveolar epithelial type II cells is indispensable for the maintenance of pulmonary function because these cells synthesize pulmonary surfactant. Approximately 90 percent of pulmonary surfactant consists of lipids, however, little is known about the deregulation of lipid composition in the pathogenesis of pulmonary diseases. We have focused on the fatty acid composition in lung and two major fatty acid catalytic enzymes, Stearoyl-CoA desaturase 1 (SCD1), that catalyzes the synthesis of monounsaturated fatty acids (MUFA) from saturated fatty acids (SFA), Elongase of long chain fatty acids 6 (Elovl6), that catalyzes the elongation of long-chain SFA and MUFA. Collectively, our results suggest that deranged fatty acid composition in alveolar type II epithelial cells leads to the onset and development of idiopathic pulmonary fibrosis or pulmonary emphysema, and also suggest that SCD1 and Elovl6 as the novel preventive or therapeutic target for these disease.

Research Products

• [Journal Article] Professional Identity Acquisition Process Model in Interprofessional Education Using Structural Equation Modelling: 10-Year Initiative Survey (2016)
  • Author(s): Nana Kururi, Fusae Tozato, Bumsuk Lee, Hiroko Kazama, Shiori Katsuyama, Maiko Takahashi, Yumiko Abe, Hiroki Matsui, Yoshiharu Tokita, Takyuki Saitoh, Shiomi Kanaizumi, Takatoshi Makino, Hiromitsu Shinozaki, Takehiko Yamji, Hideomi Watanabe
  • Journal Title: Journal of Interprofessional Care Volume: 30 Issue: 2 Pages: 175-183
  • DOI: 10.3109/13561820.2015.1092117
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Attitudes of nursing school deans toward interprofessional education in Western Pacific Region countries (2015)
  • Author(s): T. Makino, S. Nozaki, B. Lee, H. Matsui, Y. Tokita, H. Shinozaki, H. Watanabe.
  • Journal Title: Journal of Interprofessional Care Volume: 29 Issue: 5 Pages: 518-519
  • DOI: 10.3109/13561820.2015.1027337
  • Peer Reviewed / Open Access
• [Journal Article] CD36 is indispensable for thermogenesis under conditions offasting and cold stress. (2015)
  • Author(s): Putri M, Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H, Sunaga H, Koitabashi N, Matsui H, Yamazaki C, Kameo S, Tsushima Y, Yokoyama T, Koyama H, Abumrad NA, Kurabayashi M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 457 Issue: 4 Pages: 520-525
  • DOI: 10.1016/j.bbrc.2014.12.124
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Repeated cross-sectional study of the longitudinal changes in attitudes toward interprofessional health care teams amongst undergraduate students. (2014)
  • Author(s): Kururi N, Makino T, Kazama H, Tokita Y, Matsui H, Lee B, Kanaizumi S, Abe Y, Uchida Y, Asakawa Y, Shinozaki H, Tozato F, Watanabe H.
  • Journal Title: Journal of Interprofessional Care Volume: 28 Issue: 4 Pages: 285-291
  • DOI: 10.3109/13561820.2014.891977
  • Peer Reviewed
• [Journal Article] Fatty Acid Binding Protein 4 and 5 Play a Crucial Role in Thermogenesis under the Conditions of Fasting and Cold Stress (2014)
  • Author(s): Syamsunarno MR, Matsui H, 他12名
  • Journal Title: PLoS ONE Volume: 9(3) Issue: 3 Pages: 90825-90825
  • DOI: 10.1371/journal.pone.0090825
  • Peer Reviewed / Open Access
• [Journal Article] Palmitic Acid Induces Osteoblastic Differentiation in Vascular Smooth Muscle Cells through ACSL3 and NF-κB, Novel Targets of Eicosapentaenoic acid (2013)
  • Author(s): Kageyama A, Matsui H, 他7名
  • Journal Title: PLoS One Volume: 8(6) Issue: 6 Pages: e68197-e68197
  • DOI: 10.1371/journal.pone.0068197
  • Peer Reviewed
• [Journal Article] Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle (2013)
  • Author(s): Iso Tatsuya, Kurabayashi Masahiko
  • Journal Title: Arteriosclerosi Thrombosis and Vascular Biology Volume: vol.33 Issue: 11 Pages: 2549-2557
  • DOI: 10.1161/atvbaha.113.301588
  • Peer Reviewed
• [Journal Article] Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice (2013)
  • Author(s): Sunaga Hiroaki, Kurabayashi Masahiko
  • Journal Title: Nature Communications Volume: vol.4 Issue: 1 Pages: 2563-2563
  • DOI: 10.1038/ncomms3563
  • Peer Reviewed
• [Journal Article] A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting (2013)
  • Author(s): Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M
  • Journal Title: PLoS One Volume: 14;8 Issue: 11 Pages: e79386-e79386
  • DOI: 10.1371/journal.pone.0079386
  • Peer Reviewed
• [Presentation] Disrupted fatty acid composition by Elovl6 regulates phenotypic response of vascular smooth muscle cells: Novel intracellular role of AMPK-KLF4-dependent signaling. (2016)
  • Author(s): 須永 浩章, 松井 弘樹, 小出 泰暉, 小板橋 紀通, 磯 達也, 松坂 賢, 島野 仁, 倉林 正彦, 横山 知行
  • Organizer: 第80回日本循環器学会総会・学術集会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-20
• [Presentation] Elovl6-modulated long chain fatty acid composition suppresses pulmonary artery smooth muscle cell proliferation. (2016)
  • Author(s): 小出 泰暉, 松井 弘樹, 須永 浩章 , 磯 達也, 倉林 正彦， 横山 知行
  • Organizer: 第80回日本循環器学会総会・学術集会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-19
• [Presentation] Induction of a distinct phenotype of vascular smooth muscle cells in Elovl6-defieint mice: Therapeutic implication for diabetic atherosclerosis. (2016)
  • Author(s): 松井 弘樹, 須永 浩章, Mas Rizky A.A Syamsunarno, 小板橋 紀通，磯 達也 ，松坂 賢, 島野 仁, 横山 知行, 倉林 正彦
  • Organizer: 第80回日本循環器学会総会・学術集会
  • Place of Presentation: 仙台国際センター（仙台市）
  • Year and Date: 2016-03-18
• [Presentation] The fatty acid metabolism regulates phenotype of vascular smooth muscle cells via AMPK-KLF4 axis : Therapeutic implication for diabetic atherosclerosis. (2015)
  • Author(s): Hiroaki Sunaga, Hiroki Matsui, Tatsuya Iso, Takashi Matsuzaka, Hitoshi Shimano, Tomoyuki Yokoyama, Masahiko Kurabayashi
  • Organizer: 第32回国際心臓研究学会日本部会総会（ISHR2015）
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] 脂肪酸結合タンパクFABP4は急性心筋梗塞の早期診断マーカーとして有用である (2015)
  • Author(s): 須永 浩章, 磯 達也, 大山 善昭, 小保方 優, 河口 智香, 小板橋 紀通, Mas Rizky A.A Syamsunarno, 松井 弘樹, 横山 知行, 倉林 正彦
  • Organizer: 第22回日本未病システム学会学術総会
  • Place of Presentation: 北海道大学術交流会館（札幌市）
  • Year and Date: 2015-10-11
• [Presentation] 脂質の質的変化から動脈硬化の予防を考える (2015)
  • Author(s): 松井 弘樹, 横山 知行
  • Organizer: 第62回北関東医学会総会
  • Place of Presentation: 群馬大学医学部刀城会館（前橋市）
  • Year and Date: 2015-10-02
• [Presentation] Efficacy of IPE on collaborative practices-ready health workers - systematic review- (2015)
  • Author(s): Hiroki Matsui
  • Organizer: 10th Japan Interprofessional Working and Education Network (JIPWEN) Symposium
  • Place of Presentation: 群馬大学医学部ミレニアムホール（前橋市）
  • Year and Date: 2015-04-25
  • Int'l Joint Research
• [Presentation] Long chain fatty acid composition modulated by Elovl6 plays a critical role in vascular smooth muscle cell proliferation and neointimal formation (2014)
  • Author(s): Hiroki Matsui, Hiroaki Sunaga, Saki Anjo, Mas Rizky A.A Syamsunarno, Tatsuya Iso, Takashi Matsuzaka, Hitoshi Shimano, Tomoyuki Yokoyama, Masahiko Kurabayashi
  • Organizer: American Heart Association Scientific Session 2014
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2014-11-17
• [Presentation] Early Increase in Serum Fatty Acid Binding Protein 4 Levels in Patients with Acute Myocardial Infarction: Lipolysis as a novel marker for myocardial ischemia (2014)
  • Author(s): Hiroaki Sunaga, Yoshiaki Ohyama, Masaru Obokata, Tatsuya Iso, Tomoka Kawaguchi, Norimichi Koitabashi, Ryuichi Funada, Noriaki Takama, Mas Rizky A.A Syamsunarno, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
  • Organizer: American Heart Association Scientific Session 2014
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2014-11-16
• [Presentation] 心血管イベント時のダイナミックな血中FABP4濃度変化のメカニズムの解明 (2014)
  • Author(s): 須永 浩章, 磯 達也, 河口 智香, Mas Rizky A.A Syamsunarno, 松井 弘樹, 大山 善昭, 横山 知行, 倉林 正彦
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2014-07-10
• [Presentation] 脂肪酸伸長酵素Elovl6は血管平滑筋細胞の脂肪酸組成を調節することで増殖に関与する (2014)
  • Author(s): 須永 浩章, 松井 弘樹, 安生 早希, 磯 達也, 松坂 賢, 島野 仁, 横山 知行, 倉林 正彦
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2014-07-10
• [Presentation] Effects of long chain fatty acid composition regulated by Elovl6 on the proliferation of vascular smooth muscle cells (2014)
  • Author(s): Hiroki Matsui, Hiroaki Sunaga, Saki Anjo, Tatsuya Iso, Masahiko Kurabayashi, Tomoyuki Yokoyama
  • Organizer: International Vascular Biology Meeting 2014
  • Place of Presentation: 京都市勧業館みやこめっせ(京都府)
  • Year and Date: 2014-04-15
• [Presentation] Circulating FABP4 is released from adipocytes by sympathetic activation via beta3 receptor during acute cardiovascular event. (2014)
  • Author(s): Hiroaki Sunaga, Tatsuya Iso, Tomoka Kawaguchi, Mas Rizky A.A Syamsunarno, Hiroki Matsui, Yoshiaki Ohyama, Tomoyuki Yokoyama, Masahiko Kurabayashi
  • Organizer: International Vascular Biology Meeting 2014
  • Place of Presentation: 京都市勧業館みやこめっせ(京都府)
  • Year and Date: 2014-04-15
• [Presentation] Fatty acid catalytic enzymes in vascular smooth muscle cells play a crucial role in the pathogenesis of atherosclerosis
  • Author(s): Hiroki Matsui, Tomoyuki Yokoyama, Hiroaki Sunaga, Saki Anjo, Tatsuya Iso, Masahiko Kurabayashi
  • Organizer: ESC Congress 2013
  • Place of Presentation: アムステルダム（オランダ）
• [Presentation] 肺線維症における脂質代謝の変化と病態意義に関する検討
  • Author(s): 須永 浩章, 松井 弘樹, 上野 学, 前野 敏孝, 磯 達也, 松坂 賢, 島野 仁, 横山 知行, 倉林 正彦
  • Organizer: 第20回日本未病システム学会学術総会
  • Place of Presentation: 学術総合センター（東京都）
• [Presentation] 食事が血管依存性血管拡張反応（FMD）にもたらす影響について
  • Author(s): 松井 弘樹, 石井 智晃, 河口 智香, 安生 早希, 須永 浩章, 横山 知行
  • Organizer: 第20回日本未病システム学会学術総会
  • Place of Presentation: 学術総合センター（東京都）
• [Presentation] Effects of long chain fatty acid composition regulated by Elovl6 on the proliferation of vascular smooth muscle cells.
  • Author(s): 安生 早希, 松井 弘樹, 須永 浩章, 磯 達也, 倉林 正彦, 横山 知行
  • Organizer: 第78回日本循環器学会総会・学術集会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] Fatty Acid Binding Protein 4 is a direct target gene of Dll4-Notch1 pathway in Capillary Endothelial Cells in Heart.
  • Author(s): 河口 智香, 磯 達也, 矢嶋 直人, 松井 弘樹, 横山 知行, 倉林 正彦
  • Organizer: 第78回日本循環器学会総会・学術集会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] Circulating FABP4 is released from adipocytes and capillary endothelial cells by sympathetic activation via beta3 receptor during acute cardiovascular event.
  • Author(s): 河口 智香, 磯 達也, 須永 浩章, Mas Rizky A.A Syamsunarno, 松井 弘樹, 大山 善昭, 横山 知行, 倉林 正彦
  • Organizer: 第78回日本循環器学会総会・学術集会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] Fatty acid binding protein 4 and 5 differentially regulate formation of abdominal aortic aneurysm induced by calcium chloride in mice.
  • Author(s): 石井 智晃, 磯 達也, Mas Rizky AA Syamsunarno, 須永 浩章, 松井 弘樹, 小板橋 紀通, 横山 知行, 倉林 正彦
  • Organizer: 第78回日本循環器学会総会・学術集会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Remarks] 群馬大学大学院保健学研究科 生体情報検査科学講座 横山・松井研究室
  • URL: http://heart.health.gunma-u.ac.jp
• [Remarks] 群馬大学大学院保健学研究科 生体情報検査科学講座 横山研究室
  • URL: http://heart.health.gunma-u.ac.jp
• [Remarks] 群馬大学大学院保健学研究科 生体情報検査科学講座 横山研究室
  • URL: http://heart.health.gunma-u.ac.jp