| Project/Area Number |
25504003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Shimizu Makoto 東京大学, 農学生命科学研究科, 助教 (40409008)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO RYUICHIRO 東京大学, 大学院農学生命科学研究科, 教授 (50187259)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ATF4 / FGF21 / FGF15 / FGF19 / 小胞体ストレス / 機能性食品成分 / 食品成分 |
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| Outline of Final Research Achievements |
We previously reported that FGF21 and FGF19, anti-obese, anti-diabetes hormones, are novel target genes of transcription factor ATF4. In this study, we performed a screening study using cell line to identify functional food factors which activate ATF4. We found one food-derived molecule activates ATF4, and induces expression of FGF21 and FGF19 genes. Moreover, we attempted to identify novel target genes of ATF4 using microarray analysis.
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