Anti-inflammatory effects of fish-oil containing lipid emulsion in a rat model of hemorrhagic shock
Project/Area Number |
25504004
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrated Nutrition Science
|
Research Institution | Ochanomizu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
相星 淳一 東京医科歯科大学, 医学部附属病院, 講師 (50256913)
|
Research Collaborator |
SHINO Miwa
ONISAWA Keiko
SATO Machi
TAKEDA Hiromi
ITAGAKI Mai
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 救急救命医療 / 脂質栄養 / 出血性ショック / 脂質メディエーター / 質量分析 / オメガ3脂肪酸 / 脂肪乳剤 / 魚油 |
Outline of Final Research Achievements |
Omega-3 polyunsaturated fatty acids show an anti-inflammatory effects on various inflammatory diseases, while its nutritional significance for emergency therapy was not yet clear. In this study, a lipid emulsion containing fish oil was administered intraarterially 90 min before hemorrhagic shock of rat to assess the anti-inflammatory effect of Omega-3 fatty acids. It was shown that the short-term pre-administration of fish oil-containing lipid emulsion palliated hypotension and hypoxia in hemorrhagic shock, together with moderation of the severe pulmonary and intestinal disorders. Lipid metabolome analysis using liquid chromatography/electrospray ionization mass spectrometry showed the significant changes of some Omega-3 fatty acid metabolites, which may be involved in its anti-inflammatory effects on hemorrhagic shock.
|
Report
(5 results)
Research Products
(9 results)
-
[Journal Article] Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.2016
Author(s)
Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, Kobayashi T, Yamamoto T, Taketomi Y, Murakami M.
-
Journal Title
J Biol Chem.
Volume: 291
Issue: 13
Pages: 6895-6911
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.2014
Author(s)
Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M.
-
Journal Title
Cell Metab.
Volume: 20
Issue: 1
Pages: 119-132
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.2013
Author(s)
Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
-
Journal Title
J Exp Med.
Volume: 210
Issue: 6
Pages: 1217-1234
DOI
Related Report
Peer Reviewed
-
-
-