Analysis of lipotoxicity induced by fatty acids
| Project/Area Number |
25504005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
SHIMOMURA Yoshiharu 名古屋大学, 大学院生命農学研究科, 教授 (30162738)
KADOTA Yoshihiro 名古屋大学, 大学院生命農学研究科, 研究員 (10724776)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脂肪酸 / 遊離脂肪酸 / 細胞毒性 / 脂肪毒性 |
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| Outline of Final Research Achievements |
Free fatty acid (FFA) has been reported to induce cell death (lipotoxicity), but the effect depends on the carbon chain length and number of double bonds. In this study, we found that the lipotoxicity and influx rate of FFA were changed by their combinations. We also identified one of the anti-cancer FFA combination, and revealed the effect of FFA on amino acid catabolism.
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Report
(4 results)
Research Products
(6 results)
