Analysis of lipotoxicity induced by fatty acids

• Project/Area Number: 25504005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Nagoya University
• Principal Investigator: KITAURA Yasuyuki 名古屋大学, 生命農学研究科, 助教 (90442954)
• Research Collaborator: SHIMOMURA Yoshiharu 名古屋大学, 大学院生命農学研究科, 教授 (30162738) ; KADOTA Yoshihiro 名古屋大学, 大学院生命農学研究科, 研究員 (10724776)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脂肪酸 / 遊離脂肪酸 / 細胞毒性 / 脂肪毒性

Outline of Final Research Achievements

Free fatty acid (FFA) has been reported to induce cell death (lipotoxicity), but the effect depends on the carbon chain length and number of double bonds. In this study, we found that the lipotoxicity and influx rate of FFA were changed by their combinations. We also identified one of the anti-cancer FFA combination, and revealed the effect of FFA on amino acid catabolism.

Research Products

• [Journal Article] Enhanced oleate uptake and lipotoxicity associated with laurate. (2015)
  • Author(s): Kitaura Y, Inoue K, Kato N, Matsushita N, Shimomura Y.
  • Journal Title: FEBS Open Bio. Volume: 5 Issue: 1 Pages: 485-491
  • DOI: 10.1016/j.fob.2015.05.008
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Octanoic acid promotes branched-chain amino acid catabolisms via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats. (2015)
  • Author(s): Kadota Y, Toyoda T, Hayashi-Kato M, Kitaura Y, Shimomura Y.
  • Journal Title: Metabolism. Volume: 64(9) Issue: 9 Pages: 1157-1164
  • DOI: 10.1016/j.metabol.2015.05.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Regulation of hepatic branched-chain α-ketoacid dehydrogenase complex in rats fed a high-fat diet (2013)
  • Author(s): 5. Kadota, Y., Toyoda, T., Kitaura, Y., Adams, S.H., Shimomura, Y.
  • Journal Title: Obesity Research & Clinical Practice Volume: 7 (6) Issue: 6 Pages: e439-e444
  • DOI: 10.1016/j.orcp.2013.07.003
  • Peer Reviewed
• [Presentation] 肝機能及び耐糖能に対する分岐鎖アミノ酸不足の影響ーマウスモデルによる検証ー (2015)
  • Author(s): 北浦靖之
  • Organizer: 第６回 Liver Nutrition Conference in TOKAI
  • Place of Presentation: 名古屋
  • Year and Date: 2015-02-27
• [Presentation] ラウリン酸とオレイン酸による細胞死誘導促進効果の解析 (2014)
  • Author(s): 北浦靖之
  • Organizer: 第68回日本栄養・食糧学会
  • Place of Presentation: 札幌
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] The effect of combination of Lauric and Oleic acids on lipotoxicity (2013)
  • Author(s): Yasuyuki Kitaura
  • Organizer: IUNS 20th International Congress of Nutrition
  • Place of Presentation: Granada (Spain)