Elucidation of the intervening mechanism of beta-carotene in the redox status of macrophages which regulate the immunological functions.
| Project/Area Number |
25504006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Kanagawa University of Human Services (2014-2015)
The University of Tokushima (2013) |
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Principal Investigator |
Yamanishi Rintaro 神奈川県立保健福祉大学, 保健福祉学部, 教授 (30253206)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 食品成分の機能性 / 食品免疫学 / マクロファージ / グルタチオン / β-カロテン / c-Jun N-terminal Kinase / レチノイド / レチノイン酸受容体 / レチノイドＸ受容体 / アゴニスト / アンタゴニスト / グルタミン酸システインリガーゼ / β‐カロテン / JNK |
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| Outline of Final Research Achievements |
The amount of intracellular glutathione (GSH) in immune cells regulates the individual immune competence. In this study how beta-carotene elicits intracellular GSH-synthesis was investigated with a murine macrophage cultured cell line RAW264. As a result, the involvement of the signal transduction pathway mediated by c-Jun N-terminal Kinase in beta-carotene-induced GSH-synthesis in RAW264 cells was elucidated. Furthermore, retinol showed the similar activity with beta-carotene in affecting the intracellular GSH level. Despite such common activity between beta-carotene and retinol, the absence of signaling pathway consisting of retinoic acid receptor (RAR) and/or retinoid-X receptor (RXR), which would be stimulated by retinoic acid, a common metabolite between beta-carotene and retinol, from the activity was suggested.
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Report
(4 results)
Research Products
(4 results)
