| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The amount of intracellular glutathione (GSH) in immune cells regulates the individual immune competence. In this study how beta-carotene elicits intracellular GSH-synthesis was investigated with a murine macrophage cultured cell line RAW264. As a result, the involvement of the signal transduction pathway mediated by c-Jun N-terminal Kinase in beta-carotene-induced GSH-synthesis in RAW264 cells was elucidated. Furthermore, retinol showed the similar activity with beta-carotene in affecting the intracellular GSH level. Despite such common activity between beta-carotene and retinol, the absence of signaling pathway consisting of retinoic acid receptor (RAR) and/or retinoid-X receptor (RXR), which would be stimulated by retinoic acid, a common metabolite between beta-carotene and retinol, from the activity was suggested.
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