Analyses of the microRNAs regulating the expression of type 2 diabetes mellitus-susceptibility genes
| Project/Area Number |
25504007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOSHINAO GODA 静岡県立大学, 食品栄養科学部, 教授 (70195923)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生活習慣病 / 糖尿病 / microRNA / HNF1B遺伝子 / 糖尿病リスク遺伝子 / HNF1B / リスク遺伝子 |
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| Outline of Final Research Achievements |
We found the 3’UTR SNP (rs2229295) in the HNF1B gene was associated with the susceptibility of T2DM. In addition, luciferase reporter assays indicate that the substitution of C>A due to SNP (rs2229295) induces the binding of hsa-miR-214-5p/hsa-miR-550a-5p to the 3′UTR of the HNF1B gene. There is a possibility that the binding of such miRNAs regulates the expression of the HNF1B gene and susceptibility of T2DM.
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Report
(4 results)
Research Products
(2 results)
