Identification and functional analysis of food ingredients derived from regional goodies by in vivo imaging technique
Project/Area Number |
25504010
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrated Nutrition Science
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Research Institution | Wakayama Medical University |
Principal Investigator |
IHARA HAYATO 和歌山県立医科大学, 共同利用施設, 講師 (00223298)
|
Co-Investigator(Kenkyū-buntansha) |
AKAMIZU Takashi 和歌山県立医科大学, 医学部, 教授 (20231813)
KISHIDA Kunihiro 近畿大学, 生物理工学部, 講師 (30412703)
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 抗肥満効果 / 機能性食品成分 / 生体イメージング / 機能性成分 / UCP-1遺伝子 / 分子生理機能 / 脂肪細胞 / 果実由来機能性成分 |
Outline of Final Research Achievements |
1. Examined the effects of hydroxycinnamic acids on gene expression of adipokines in 3T3-L1 adipocytes. . Among them, caffeic acid significantly reduced resistin, which causes insulin resistance state, gene expression dose dependently. In addition, caffeic acid also reduced resistin-reporter gene expression in stable adipocytes. After transplantation of these stable cells into inguinal fat pads of nude mice, administration of caffeic acid also reduced the reporter-gene expression in vivo. 2. We have examined effects of an another compound (patent pending) derived from regional goodies on high fat diet (HFD)-induced weight gain. C57BL/6 mice fed an HFD with this compound (3% w/w) significantly leaded to a reduced weight gain only after 1-week period compared with HFD-fed mice, and leaded to an induction of UCP-1 gene expression in inguinal fat pads.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Annual variation in the atmospheric radon concentration in Japan.2015
Author(s)
Yuka Kobayashi, Yumi Yasuoka, Yasutaka Omori, Hiroyuki Nagahama, Tetsuya Sanada, Jun Muto, Toshiyuki Suzuki, Yoshimi Homma, Hayato Ihara, Kazuhito Kubota, Takahiro Mukai
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Journal Title
Journal of Environmental Radioactivity
Volume: 146
Pages: 110-118
Related Report
Peer Reviewed
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