| Project/Area Number |
25504014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡邉 マキノ 順天堂大学, 医学部, 准教授 (00255655)
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| Co-Investigator(Renkei-kenkyūsha) |
Hashimoto Ryota 順天堂大学, 医学部, 助教 (60433786)
Kakigi Ryo 順天堂大学, 医学部, 助教 (70614931)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血管内皮細胞 / 一酸化窒素 / 血管弛緩反応 / フコイダン / 一酸化窒素合成酵素 / 虚血-再灌流障害 |
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| Outline of Final Research Achievements |
Fucoidan is a natural sulfated polysaccharide obtained from brown marine algae composed predominantly of sulfated fucose. The objectives of the present study are to investigate the effects of fucoidan on cardiovascular system and to explore the mechanism(s) of action, leading to the clarification of scientific basis of its usefulness as a functional food. The present study showed that fucoidan caused vascular relaxation through endothelium-dependent, nitric oxide (NO)-mediated mechanism in isolated rat aorta and this relaxation seemed to be caused through an activation of endothelial nitric oxide synthase (eNOS).
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