A study of hydrogen sulfide donor to prevent alzheimer's disease
| Project/Area Number |
25504015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Nihon University |
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Principal Investigator |
HOSONO Takashi 日本大学, 生物資源科学部, 講師 (80445741)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アルツハイマー病 / 硫化水素 / ガーリック / 神経細胞 / アミロイドβ / PC12細胞 / 初代培養神経細胞 / グルタチオン / SH基 |
|---|
| Outline of Final Research Achievements |
The aim of this study was to investigate the protective effect of food factor on Alzheimer's disease. We found that diallyl trisulfide (DATS) derived from garlic is hydrogen sulfide donor compound. Amyloid β induced neuronal cell death in primary neuronal cell cultures and neuronal cell line PC12. DATS and other hydrogen sulfide donor compounds had little effects on neuronal cell death induced by amyloid β. We revealed that DATS has anti-inflammatory activity.
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Report
(5 results)
Research Products
(34 results)
