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Evaluation of vitamin E status using urinary excretion of vitamin E metabolites

Research Project

Project/Area Number 25504017
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionNagoya University of Arts and Sciences

Principal Investigator

Ikeda Saiko  名古屋学芸大学, 管理栄養学部, 教授 (80308808)

Co-Investigator(Kenkyū-buntansha) NOMURA SAKI  名古屋学芸大学, 管理栄養学部, 助手 (90588956)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
KeywordsビタミンE / トコフェロール
Outline of Final Research Achievements

We examined the effect of tocopherol supplementation on its metabolite (CEHC) excretion. Study 1: Tocopherol intake, serum tocopherol concentration, and urinary excretion of CEHC of healthy young women was measured. Neither gamma-tocopherol intake nor serum gamma-tocopherol concentration was correlated with gamma-CEHC excretion, although gamma-tocopherol intake was correlated with serum gamma-tocopherol concentration. Study 2: Healthy young people took 100 mg of alpha-tocopherol, 100 mg of gamma-tocopherol, or placebo. The result that increases of serum tocopherol concentration and urinary CEHC excretion, suggested fast catabolism of gamma-tocopherol compared with alpha-tocopherol. Study 3: Healthy young women took gamma-tocopherol (100 mg/d), or gamma-tocopherol (100 mg/d) with alpha-tocopherol (50 mg/d), for 7 days. Gamma-tocopherol intake lowered serum alpha-tocopherol concentration and enhanced CEHC excretion, suggesting accerelation of alpha-tocopherol catabolism.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 若年女性におけるγ-トコフェロール代謝についての検討2016

    • Author(s)
      内田友乃 小池泰介 池田彩子
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大学
    • Year and Date
      2016-05-13
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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