Evaluation of vitamin E status using urinary excretion of vitamin E metabolites
| Project/Area Number |
25504017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Nagoya University of Arts and Sciences |
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Principal Investigator |
Ikeda Saiko 名古屋学芸大学, 管理栄養学部, 教授 (80308808)
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA SAKI 名古屋学芸大学, 管理栄養学部, 助手 (90588956)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | ビタミンE / トコフェロール |
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| Outline of Final Research Achievements |
We examined the effect of tocopherol supplementation on its metabolite (CEHC) excretion. Study 1: Tocopherol intake, serum tocopherol concentration, and urinary excretion of CEHC of healthy young women was measured. Neither gamma-tocopherol intake nor serum gamma-tocopherol concentration was correlated with gamma-CEHC excretion, although gamma-tocopherol intake was correlated with serum gamma-tocopherol concentration. Study 2: Healthy young people took 100 mg of alpha-tocopherol, 100 mg of gamma-tocopherol, or placebo. The result that increases of serum tocopherol concentration and urinary CEHC excretion, suggested fast catabolism of gamma-tocopherol compared with alpha-tocopherol. Study 3: Healthy young women took gamma-tocopherol (100 mg/d), or gamma-tocopherol (100 mg/d) with alpha-tocopherol (50 mg/d), for 7 days. Gamma-tocopherol intake lowered serum alpha-tocopherol concentration and enhanced CEHC excretion, suggesting accerelation of alpha-tocopherol catabolism.
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Report
(4 results)
Research Products
(1 results)
