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The use of functional nanocomposite structure for the development of novel functional food for specified health uses

Research Project

Project/Area Number 25504018
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionOsaka University of Pharmaceutical Sciences

Principal Investigator

TOZUKA YUICHI  大阪薬科大学, 薬学部, 教授 (50312963)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsナノコンポジット / 糖転移へスぺリジン / 糖転移ルチン / 糖転移ステビア / 糖転移ナリンジン / 溶解性改善 / 吸収性改善 / 光安定性向上 / 溶解度改善 / 難水溶性化合物 / 糖転移ヘスペリジン
Outline of Final Research Achievements

Poor water solubility of food constituent may lead to a crucial absorption problem. To overcome this problem, the feasibility of recently developed transglycosylated additives, e.g., α-glucosyl hesperidin, α-glucosyl stevia, and α-glucosyl rutin, to improve the dissolution and bioavailability of food ingredient was investigated. We found that trans-glycosylated materials formed self-associated aggregated-nanostructures in aqueous media, and their structure was different among three. The poorly water soluble food compounds could intercorporate the nanostructure, creating nanocomposite structure of hydrophobic food compounds/transglycosylated additives. Moreover, we found that the nanocomposite formation may also protect hydrophobic food compounds from hydrolytic degradation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (28 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 5 results) Presentation (20 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Low hygroscopic spray-dried powders with trans-glycosylated food additives for enhanced solubility and oral bioavailability of a ipriflavone2016

    • Author(s)
      M. Fujimori, K. Kadota, K. Kato, Y. Seto, S. Onoue, H. Sato, H. Ueda, Y. Tozuka
    • Journal Title

      Food. Chem.

      Volume: 190 Pages: 1050-1055

    • DOI

      10.1016/j.foodchem.2015.06.081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Soluble hydrolysis-resistant composite formulation of curcumin containing α-glucosyl hesperidin and polyvinylpyrrolidone2016

    • Author(s)
      K. Kadota, S. Otsu, M. Fujimori, H. Sato, Y. Tozuka
    • Journal Title

      Adv. Powder Tech.

      Volume: 27 Issue: 2 Pages: 442-447

    • DOI

      10.1016/j.apt.2016.01.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inhibited photodegradation of highly-dispersed folic acid nanoparticles by antioxidant effect of transglycosylated rutin2016

    • Author(s)
      K. Kadota, K. Semba, R. Shakudo, H. Sato, Y. Deki, Y. Shirakawa, Y. Tozuka
    • Journal Title

      J. Agr. Food. Chem.

      Volume: 64 Issue: 15 Pages: 3062-3069

    • DOI

      10.1021/acs.jafc.6b00334

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Enhanced dissolution of quercetin by forming composite particles2015

    • Author(s)
      M. Fujimori, K. Kadota, K. Shimono, Y Shirakawa, H. Sato, Y. Tozuka
    • Journal Title

      J. Food Eng.

      Volume: 149 Pages: 248-254

    • DOI

      10.1016/j.jfoodeng.2014.10.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Absorption improvement of tranilast by forming highly soluble nano-size composite structures associated with α-glucosyl rutin2015

    • Author(s)
      H. Sato, M. Fujimori, H. Suzuki, K. Kadota, Y. Shirakawa, S. Onoue, Y. Tozuka
    • Journal Title

      Euro. J. Pharm. Biopharm.

      Volume: 92 Pages: 49-55

    • DOI

      10.1016/j.ejpb.2015.02.021

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Drug solubilization mechanism of alpha-glucosyl stevia by NMR spectroscopy2014

    • Author(s)
      Zhang, J., Higashi, K., Ueda, K., Kadota, K., Tozuka, Y., Limwikrant, W., Yamamoto, K., Moribe, K.
    • Journal Title

      Int. J. Pharm.

      Volume: 465 (1-2) Issue: 1-2 Pages: 255-261

    • DOI

      10.1016/j.ijpharm.2014.01.035

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 糖転移ナリンジンによる難水溶性薬物のカルボキシル基に起因した溶解性改善2016

    • Author(s)
      岡本大樹、藤森美季、門田和紀、戸塚裕一
    • Organizer
      日本薬学会136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 機能性食品添加剤を粉砕媒体として利用した湿式ビーズミルによる葉酸ナノ粒子作製2016

    • Author(s)
      門田和紀、仙波久実、戸塚裕一
    • Organizer
      化学工学会第81年会
    • Place of Presentation
      大阪
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Highly-soluble and hydrolytic degradation-preventing formulation of curcumin using α-transglycosylated hesperidin and polyvinylpyrrolidone2015

    • Author(s)
      Y. Tozuka, S. Otsu, M. Fujimori, H. Sato, K. Kadota
    • Organizer
      Food structures, Digestion and Health, 3rd International Conference
    • Place of Presentation
      Wellington, New Zealand
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Folic acid nanoparticle production with highly dispersion and photostability using α-glycosyl rutin2015

    • Author(s)
      K. Kadota, K. Semba, R. Shakudo, H. Sato, Y. Tozuka
    • Organizer
      Food structures, Digestion and Health, 3rd International Conference
    • Place of Presentation
      Wellington, New Zealand
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖転移ステビアのミセル形成能を利用した医薬品の溶解性改善2015

    • Author(s)
      桑元俊輔、藤森美季、門田和紀、戸塚裕一
    • Organizer
      粉体工学会2015年度秋期研究発表会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高圧湿式微粒化装置による酵素処理ルチンを粉砕媒体としたイトラコナゾールの溶解性改善2015

    • Author(s)
      藤江美加、赤土了介、森岡俊光、橋爪宏太、門田和紀、戸塚裕一
    • Organizer
      第40回製剤・創剤セミナー
    • Place of Presentation
      兵庫
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 酵素処理ルチンによる光安定性改善を指向した葉酸ナノ粒子の作製2015

    • Author(s)
      仙波久実、赤土了介、藤森美季、門田和紀、戸塚裕一
    • Organizer
      第40回製剤・創剤セミナー
    • Place of Presentation
      兵庫
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Nanocomposite formation of drug/trans-glycosylated additive for creating functional powders2015

    • Author(s)
      Y. Tozuka
    • Organizer
      The 5th International Conference on the Characterization and Control of Interfaces for High Quality Advanced Materials and the 51st Summer Symposium on Powder Technology
    • Place of Presentation
      Okayama
    • Year and Date
      2015-07-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] α-Glycosyl Stevia と界面活性剤の複合体形成による pH 非依存性製剤の設計2015

    • Author(s)
      桑元俊輔、藤森美季、佐藤秀行、門田和紀、戸塚裕一
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Curcumin の溶解度及び化学的安定性向上を指向した複合粒子の開発2015

    • Author(s)
      大津誠行、大熊加奈子、佐藤秀行、門田和紀、戸塚裕一
    • Organizer
      粉体工学会2015年度春期研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Stabilizing effect of cyclodextrins on the water-soluble nanocomposite formulation of curcumin and transglycosylated aditives2015

    • Author(s)
      Y. Tozuka, S. Otsu, K. Okuma, H. Sato, K. Kadota
    • Organizer
      Joint conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium
    • Place of Presentation
      Kumamoto
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Solubility enhancement of hydrophobic flavones by forming a nano-structured complex with transglycosylated food additives2014

    • Author(s)
      Y. Tozuka, M. Fujimori, S. Nakashiro, H. Sato, K. Kadota
    • Organizer
      28th the European Federation of Food Science and Technology
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2014-11-25 – 2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖転移ルチン(Rutin-G)による難溶性薬物Tranilastの高吸収性製剤の開発2014

    • Author(s)
      佐藤秀行、藤森美季、鈴木寛貴、門田和紀、尾上誠良、戸塚裕一
    • Organizer
      第31回製剤と粒子設計シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2014-10-23 – 2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 小角X線散乱及びNMR測定によるα-Glucosyl hesperidin会合構造の評価2014

    • Author(s)
      竹内喜大、東顕二郎、森田 剛、門田和紀、戸塚裕一、山本恵司、森部久仁一
    • Organizer
      第58回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Enhanced dissolution of quercetin by forming composite particles via spray-drying2014

    • Author(s)
      Y. Tozuka, M. Fujimori, K. Shimono, Y. Shirakawa, K. Kadota
    • Organizer
      19th International Symposium on Industrial Crystallization
    • Place of Presentation
      Toulouse, France
    • Year and Date
      2014-09-16 – 2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 機能性食品添加剤の分子間相互作用を利用した機能性複合粒子の調製2014

    • Author(s)
      門田和紀、藤森美季、戸塚裕一
    • Organizer
      粉体工学会2014年度春期研究発表会
    • Place of Presentation
      京都
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖転移化合物が難水溶性薬物Ipriflavoneの溶解性に与える影響2014

    • Author(s)
      中代 里美、相澤 恭、門田 和紀、戸塚 裕一
    • Organizer
      日本薬学会134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] Quercetinの抗酸化作用向上のための固体分散体の調製2014

    • Author(s)
      藤森 美季、中代 里美、相澤 恭、門田 和紀、戸塚 裕一
    • Organizer
      日本薬学会134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] Dissolution and absorption enhancement of flurbiprofen induced by non-surface-active nanostructure of transglycosylated rutin2013

    • Author(s)
      Y. Tozuka, K. Higashi, K. Moribe, H. Takeuchi, K. Yamamoto
    • Organizer
      5th Asian Arden Conference
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 界面張力変化を伴わないナノコンポジット形成による難水溶性化合物の可溶化と吸収性改善2013

    • Author(s)
      戸塚 裕一、東 顕二郎、森部 久仁一、竹内 洋文、山本 恵司
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] α-グルコシルルチン含有プテリジン誘導体ナノ粒子の製造方法およびα-グルコシルルチン含有プテリジン誘導体ナノ粒子2015

    • Inventor(s)
      門田和紀, 戸塚裕一, 長井敦史, 相澤恭
    • Industrial Property Rights Holder
      東洋精糖株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-152068
    • Filing Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 水溶性組成物、その製造方法および難水溶性物質の溶解性改善方法2015

    • Inventor(s)
      戸塚裕一, 門田和紀, 長井敦史, 相澤恭
    • Industrial Property Rights Holder
      東洋精糖株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-170659
    • Filing Date
      2015-08-31
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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