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Resveratrol ameliorates high-fat-diet-induced fatty liver by increasing CD68 positive Kupffer cells.

Research Project

Project/Area Number 25504021
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionChuo University (2015)
National Defense Medical College (2013-2014)

Principal Investigator

Nishikawa Kahoko  中央大学, 商学部, 教授 (20345416)

Co-Investigator(Kenkyū-buntansha) Seki Shuji  防衛医科大学校, 免疫微生物学, 教授 (80531392)
Kinoshita Manabu  防衛医科大学校, 免疫微生物学, 準教授 (70531391)
Iwaya Keiichi  公益財団法人佐々木研究所, 病理部病理診断科, 部長 (50312012)
Ono Satoshi  東京医科大学, 八王子医療センター特定集中治療部, 教授 (30531355)
Fujiwara Yoko  お茶の水女子大学, 生活科学部 栄養学科, 教授 (50293105)
Sakamoto Toshihisa  防衛医科大学校病院, 救急部, 部長 (50178571)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsレスベラトロール / 脂肪肝 / クッパー細胞 / ADFP / 脂肪滴
Outline of Final Research Achievements

Resveratrol is a phytoalexin polyphenolic compound present in various plants, including grapes and peanuts. Multiple lines of evidence suggest that resveratrol has beneficial effects on human health. Liver macrophages, or Kupffer cells, are suggested to be one of the major immune effectors in the pathogenesis of steatohepatitis. However, the mechanisms underlying increased lipid content in the steatohepatitic liver and the involvement of Kupffer cells are still poorly understood. We hypothesized that certain liver proteins modulated by resveratrolmight interact with Kupffer cells, and investigated the target protein underlying the ability of resveratrol to improve fatty liver. Our results provide evidence that resveratrol increases the number of CD68+ Kupffer cells in the liver and it may be involved in reduction of LDs. Our findings provide new insight into the beneficial effects of resveratrol on hepatic lipid metabolism in the context of the modulation of Kupffer cell function.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Resveratrol increases CD68+ Kupffer cells colocalized with adipose differentiation-related protein and ameliorates high-fat-diet-induced fatty liver in mice.2015

    • Author(s)
      Nishikawa K, Iwaya K, Kinoshita M, Fujiwara Y, Akao M, Sonoda M, Thiruppathi S, Suzuki T, Hiroi S, Seki S, Sakamoto T.
    • Journal Title

      Mol Nutr Food Res

      Volume: 12 Issue: 6 Pages: 564-564

    • DOI

      10.1002/mnfr.201400564

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mep72: A metzincin protease that is preferentially secreted by biofilms of Pseudomonas aeruginosa.2015

    • Author(s)
      Ian Passmore, Kahoko Nishikawa, Kathryn Lilley, Steven Bowden, Jade Chung, and Martin Welch
    • Journal Title

      Journal of Bacteriology

      Volume: 197 Issue: 4 Pages: 762-73

    • DOI

      10.1128/jb.02404-14

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment with fibrinogen γ-chain peptide-coated, adenosine 5'-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia2015

    • Author(s)
      Hagisawa K, Nishikawa K, Yanagawa R, Kinoshita M, Doi M, Suzuki H, Iwaya K, Saitoh D, Seki S, Takeoka S, Handa M, Nishida Y.
    • Journal Title

      Transfusion.

      Volume: 55 Issue: 2 Pages: 314-325

    • DOI

      10.1111/trf.12829

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of changes in the structure and distribution map of triacylglycerol in fatty liver model by MALDI-Spiral TOF2014

    • Author(s)
      Nishikawa K, Hashimoto M, Itoh Y, Hiroi S, Kusai A, Hirata F, Sakamoto T, Iwaya K
    • Journal Title

      FEBS Open Bop

      Volume: 19 Issue: 1 Pages: 179-84

    • DOI

      10.1016/j.fob.2014.02.005

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Resveratrol increases cd68+kupffer cells co-localized with adipose differentiation-related protein (adfp) and ameliorates high-fat-diet-induced fatty liver in mice.2015

    • Author(s)
      K Nishikawa, K .Iwaya, M Knoshita, Y Fujiwara, S Thiuppathi, T Suzuki, S Seki, T Sakamoto
    • Organizer
      4th European Congress of Immunology 2015
    • Place of Presentation
      ウィーン (オーストリア )
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Resveratrol ameliorates fatty liver by reducing the size of lipid droplet without changing liver fat species.2014

    • Author(s)
      K. Nishikawa, M. Hashimoto, Y. Itoh, S. Hiroi, T.Sakamoto, K. Iwaya
    • Organizer
      FEBS EMBO 2014 Conference
    • Place of Presentation
      Palais des Congrès, Paris, France
    • Year and Date
      2014-08-30 – 2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 食餌性レスベラトロールが肝臓に蓄積する中性脂肪へ与える影響2013

    • Author(s)
      西川可穂子、橋本将弘、久保歩、阪本敏久、岩屋啓一
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] Resveratrol increases CD68 positive Kupffer cells with phagocytic activity to lipid droplets and ameliorates high-fat diet induced fatty liver in mice2013

    • Author(s)
      Nishikawa K, Kinoshita M, Iwaya K, Sakamoto T, Seki S.
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張(千葉)
    • Related Report
      2013 Research-status Report
  • [Book] シリーズ 「おもしろサイエンス 機能性野菜の科学」2016

    • Author(s)
      佐竹元吉監修 一部 西川執筆担当
    • Publisher
      日刊工業新聞社
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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