| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Mesenchymal stromal cells (MSCs) have the differentiation ability to mesenchymal lineage cells in culture and maintain the quiescent state in adult tissues. Because MSCs have been defined using cells cultured in vitro, discrepancies have arisen between studies concerning their properties. Using prospective isolation method for human and mouse MSCs, we performed the clonal analysis of MSCs about maintaining the quiescence. Clonal characterization of MSCs demonstrated that the transmembrane protein teneurin-4 (Ten-4) is highly expressed in the quiescent MSCs. The cell culture analysis showed that Ten-4 was downregulated in MSC after differentiation. Our findings revealed that Ten-4 player a role in maintaining the quiescence of MSCs.
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