Analysis of gravity sensor for medaka osteoclast via space experiment
| Project/Area Number |
25514003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命学
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| Research Institution | Showa University (2016)
Tokyo Institute of Technology (2013-2015) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 宇宙 / 骨 / メダカ / 破骨細胞 / 重力 / 宇宙実験 / 骨芽細胞 / 骨生物学 / 骨量減少 / 微小重力環境 |
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| Outline of Final Research Achievements |
Space flight in a reduced gravity environment can have lasting effects on the body. For example, astronauts undergo a significant drop in bone mineral density during space mission, but the molecular mechanisms responsible for such changes in bone density are unclear. To identify the mechanisms, twice unique experiments were performed at international space station by using medaka fish. One was long-term experiment for analysis of bone growth during 2 months, resulting in the decrease of mineral density for pharyngeal teeth bones. Another was short-term experiment for live-imaging of transgenic medaka lines and transcriptome analysis during 8 days, resulting in the increase of the expression levels for 5 genes. Taken together, medaka fish studies give scientists a good starting point to figure out how the process actually occurs.
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Microgravity promotes osteoclast activity in medaka fish reared at the international space station2015
Author(s)
Masahiro Chatani, Akiko Mantoku, Kazuhiro Takeyama, Dawud Abduweri, Yasutaka Sugamori, Kazuhiro Aoki, Keiichi Ohya, Hiromi Suzuki, Satoko Uchida, Toru Sakimura, Yasushi Kono, Fumiaki Tanigaki, Masaki Shirakawa, Yoshiro Takano and *Akira Kudo
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 14172-14172
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Histological and transcriptomic analysis of adult Japanese medaka sampled onboard the international space station2015
Author(s)
Yasuhiko Murata, Takako Yasuda, Tomomi Watanabe-Asaka, Shoji Oda, Akiko, Mantoku, Kazuhiro Takeyama, Masahiro Chatani, Akira Kudo, Satoko Uchida, Hiromi Suzuki, Fumiaki Tanigaki, Masaki Shirakawa, Koichi Fujisawa, Yoshihiko, Hamamoto, *Shuji Terai, *Hiroshi Mitani
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Journal Title
PLOS ONE
Volume: 10
Issue: 10
Pages: e0138799-e0138799
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Early response to microgravity in the analysis of whole transcriptome and live imaging2015
Author(s)
Masahiro Chatani, Akiko Mantoku, Kazuhiro Takeyama, Hiroya Morimoto, Takehiko Ito, Naoki Tanigawa, Koji Kubota, Hiromi Suzuki, Satoko Uchida, Fumiaki Tanigaki, Masaki Shirakawa, Yoshiro Takano, Akira Kudo
Organizer
米国骨代謝学会（ASBMR; American Society for Bone and Mineral Research, Annual Meeting）
Place of Presentation
Washington State Convention Center, Seattle, Washington, USA
Year and Date
2015-10-09
Related Report
Int'l Joint Research
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