| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Space flight in a reduced gravity environment can have lasting effects on the body. For example, astronauts undergo a significant drop in bone mineral density during space mission, but the molecular mechanisms responsible for such changes in bone density are unclear. To identify the mechanisms, twice unique experiments were performed at international space station by using medaka fish. One was long-term experiment for analysis of bone growth during 2 months, resulting in the decrease of mineral density for pharyngeal teeth bones. Another was short-term experiment for live-imaging of transgenic medaka lines and transcriptome analysis during 8 days, resulting in the increase of the expression levels for 5 genes. Taken together, medaka fish studies give scientists a good starting point to figure out how the process actually occurs.
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