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Clinical Trial of Tongue Stabilizing Device for Down Syndrome Patients with Obstructive Sleep Apnea

Research Project

Project/Area Number 25515002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 睡眠科学
Research InstitutionKyushu University

Principal Investigator

Inoue Hiroko  九州大学, 大学病院, 研究員 (50593795)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords睡眠 / 歯科 / ダウン症 / 無呼吸 / 睡眠時無呼吸
Outline of Final Research Achievements

To reveal the prevalence of tongue stabilizing device (TSD) candidate and these patient characteristics, we examined it at principal investigator’s university hospital. As a result, it is suggested that almost 20 percent of obstructive sleep apnea (OSA) patients who aim to have oral appliance therapy are not appropriate for conventional mandibular advancement device, and TSD could be an only treatment option for them.
Following this study, we conducted a clinical trial of TSD for Down Syndrome Patients with OSA. Study subjects were recruited from member of Fukuoka branch of Japan Down Syndrome Society. To evaluate treatment efficacy of TSD in Down syndrome with OSA, ten subjects’ data were collected. Because not enough number of participants for statistical analysis, and no participants who could tolerate TSD use in trial term, it was abandoned this recruitment and statistical analysis. These results were presented and discussed at Japanese and international scientific meetings.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 9 results) Book (1 results)

  • [Journal Article] Oral Appliances for the treatment of Obstructive Sleep Apnea: An Update2014

    • Author(s)
      Kate Sutherland, Olivier M. Vanderveken, Hiroko Tsuda, Marie Marklund, Frederic Gagnadoux, Clete A. Kushida, Peter A. Cistulli
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: 10 Issue: 02 Pages: 215-227

    • DOI

      10.5664/jcsm.3460

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Requirement for sleep medicine education in Japanese pre-doctoral dental curriculum2014

    • Author(s)
      Hiroko Tsuda, Tomomi Ohmaru and Yoshinori Higuchi
    • Journal Title

      Sleep and Biological Rhythms

      Volume: -

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Unrecognized craniofacial consequences of pediatric CPAP2016

    • Author(s)
      Hiroko Tsuda
    • Organizer
      The 4th International Pediatric Sleep Association Congress
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] OA治療のエビデンスと歯科における臨床の流れ2015

    • Author(s)
      津田緩子
    • Organizer
      日本臨床睡眠医学会
    • Place of Presentation
      梅田スカイビル 大阪
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dentofacial Consequences of CPAP2015

    • Author(s)
      Hiroko Tsuda
    • Organizer
      American Academy of Dental Sleep Medicine
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 睡眠時無呼吸の現状と今後の展開2015

    • Author(s)
      津田緩子
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      埼玉ソニックシティ 埼玉
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Nasal CPAP, oralfacial growth in children2015

    • Author(s)
      Hiroko Tsuda
    • Organizer
      World Congress on Sleep Medicine
    • Place of Presentation
      ソウル、大韓民国
    • Year and Date
      2015-03-21 – 2015-03-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 睡眠時無呼吸のための口腔内装置治療 -CPAPと比較した長所・短所-2015

    • Author(s)
      津田 緩子
    • Organizer
      さいたま循環器SASセミナー
    • Place of Presentation
      ホテルブリランテ武蔵野
    • Year and Date
      2015-01-31
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Complexity and efficacy of mandibular splints in adult OSA2015

    • Author(s)
      Hiroko Tsuda
    • Organizer
      Seminars of Ortodontiakeskus
    • Place of Presentation
      タリン、エストニア
    • Year and Date
      2015-01-08 – 2015-01-10
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] SAS連携医療の中での口腔内装置治療の位置づけ2014

    • Author(s)
      津田 緩子
    • Organizer
      第5回睡眠時無呼吸症候群学術講演会
    • Place of Presentation
      ホテルサンルート徳山
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 閉塞型無呼吸に対する口腔内装置治療の治療効果と適応上の課題について2014

    • Author(s)
      津田 緩子
    • Organizer
      日本睡眠学会 第39回定期学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 睡眠時無呼吸症候群の歯科的治療の最前線2014

    • Author(s)
      津田 緩子
    • Organizer
      睡眠時無呼吸症候群特別講演会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-05-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 睡眠歯科外来の患者動向と治療成績の検討,日本睡眠学会第38回定期学術集会2013

    • Author(s)
      波多野千尋, 津田 緩子, 森槌 康貴, 村岡 奈々美, 永田 しの, 郡司掛 友世, 一木 克之, 自見 勇郎, 加藤 香織, 津田 徹
    • Organizer
      日本睡眠学会第38回定期学術集会
    • Place of Presentation
      秋田
    • Related Report
      2013 Research-status Report
  • [Presentation] 睡眠時無呼吸に対する口腔内装置不適応症例の動向と舌前方整位装置(TSD)の応用2013

    • Author(s)
      津田 緩子
    • Organizer
      日本睡眠学会第38回定期学術集会
    • Place of Presentation
      秋田
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 睡眠時無呼吸症―広がるSAS診療―2013

    • Author(s)
      津田緩子(分担執筆) (塩見利明編)
    • Total Pages
      264
    • Publisher
      朝倉書店
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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