Study on the relationship between arthritis and the quality of sleep
Project/Area Number |
25515003
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
睡眠科学
|
Research Institution | Kyushu University |
Principal Investigator |
Shiozawa Shunichi 九州大学, 大学病院, 学術研究員(特任教授) (40154166)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 関節リウマチ / 睡眠 / 生物学的製剤 / rheumatoid arthritis / sleep / biological DMARDs / 睡眠の質 / quality of sleep / 概日リズム / 疾患活動性 / 日常生活動作 / 睡眠障害 / メラトニン作動薬 / ラメルテオン |
Outline of Final Research Achievements |
The contribution of inflammation (arthritis) to the quality of sleep and vise versa was studied in the patients with rheumatoid arthritis (RA). We have studied 517 patients with rheumatoid arthritis with biologic DMARDs (tocilizmab 175, abatacept 98, or infliximab 144). Evaluation was made with Pittsburgh score, Epworth score and actigraphy, and the results were compared with arthritic indices. As a result, Pittsburgh score showed presence of sleep disturbance, in which global score showed 6.42±2.76 which was higher than normal level 5, thus indicating the presence of sleep disturbance. Actigraphy showed that %sleep 89.1±10.5, total wake after sleep 49.5±45.2 min, average wake after sleep onset 9.9±23.3times, and these values were abnormal as compared with healthy controls. Further, these values showed a posistive correlation with C-reactive protein levels and swollen joint counts of patients. After biologic DMARDs treatments (n=517), these abnormalities were all normalized.
|
Report
(4 results)
Research Products
(37 results)
-
-
-
[Journal Article] The Impact of c-Fos/Activator Protein-1 Inhibition on Allogeneic Pancreatic Islet Transplantation.2015
Author(s)
Yoshida T, Yamashita K, Watanabe M, Koshizuka Y, Kuraya D, Ogura M, Asahi Y, Ono H, Emoto S, Mizukami T, Kobayashi N, Shibasaki S, Tomaru U, Kamachi H, Matsushita M, Shiozawa S, Hirono S, Todo S.
-
Journal Title
Am J Transplant.
Volume: 15(10)
Issue: 10
Pages: 2565-2575
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] The impact of c-Fos/Activator protein-1 inhibition on allogeneic pancreatic islet transplantation.2015
Author(s)
Yoshida T, Yamashita K, Watanabe M, Koshizuka Y, Kuraya D, Ogura M, Asahi Y, Ono H, Emoto S, Mizukami T, Kobayashi N, Shibasaki S, Tomaru U, Kamachi H, Matsushita M, Shiozawa S, Hirono S, Todo S.
-
Journal Title
Am J Transplantation
Volume: in press
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
[Journal Article] Amerged presentation of clinical and radiographic data using probability plots in a clinical trial, the JESMR study2013
Author(s)
Kameda H, Kanbe K, Sato E, Ueki Y, Saito K, Nagaoka S, Hidaka T, Atsumi T, Tsukano M, Kasama T, Shiozawa S, Tanaka Y, Yamanaka H, Takeuchi T
-
Journal Title
Ann Rheum Dis
Volume: 72
Issue: 2
Pages: 310-2
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 器官病理学2013
Author(s)
塩沢俊一(分担執筆)
Total Pages
1018
Publisher
南山堂
Related Report
-
[Book] 永井書店2013
Author(s)
塩沢俊一他編
Total Pages
269
Publisher
リウマチ病セミナー
Related Report
-