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Personalized Therapy According to the Phenotype of Obstructive Sleep Apnea - Exploring the Efficacy of the Pharmacological Therapy -

Research Project

Project/Area Number 25515004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 睡眠科学
Research InstitutionNara Medical University

Principal Investigator

Yamamauchi Motoo  奈良県立医科大学, 医学部, 講師 (30405378)

Co-Investigator(Kenkyū-buntansha) Kimura Hiroshi  奈良県立医科大学, 医学部, 教授 (20195374)
Yoshikawa Masanori  奈良県立医科大学, 医学部, 准教授 (80271203)
Fujita Yukio  奈良県立医科大学, 医学部, 助教 (60571023)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords閉塞性睡眠時無呼吸症候群 / 呼吸不規則性 / 薬物療法 / 呼吸生理 / 個別化医療 / 睡眠時無呼吸症候群 / CPAP
Outline of Final Research Achievements

Although standard therapy for obstructive sleep apnea is CPAP, there are not a few patients who are intolerant to CPAP. However, alternative and/or complemental therapy has not been so far established. Regarding the pharmacological therapy for OSA, there are many reports with the controversial results. In the current study, we demonstrated that specific pharmacological therapy might be useful for the improvement of OSA and CPAP adherence, as long as we prescribe medicine to OSA who are expected to respond.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (27 results)

All 2016 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (15 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (4 results)

  • [Journal Article] Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure.2016

    • Author(s)
      Kihara Y, Seino Y, Momomura S; SAVIOR-C investigators.
    • Journal Title

      N Engl J Med.

      Volume: 374(7) Issue: 7 Pages: 687-8

    • DOI

      10.1056/nejmc1515007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonrapid Eye Movement-Predominant Obstructive Sleep Apnea: Detection and Mechanism.2015

    • Author(s)
      Yamauchi M, Fujita Y, Kumamoto M, Yoshikawa M, Ohnishi Y, Nakano H, Strohl KP, Kimura H
    • Journal Title

      J Clin Sleep Med

      Volume: 11 Issue: 09 Pages: 987-993

    • DOI

      10.5664/jcsm.5010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nonrapid Eye Movement-Predominant Obstructive Sleep Apnea: Detection and Mechanism.2015

    • Author(s)
      Yamauchi M, Fujita Y, Kumamoto M, Yoshikawa M, Ohnishi Y, Nakano H, Strohl KP, Kimura H.
    • Journal Title

      J Clin Sleep Med

      Volume: N/A

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of environment light during sleep on autonomic functions of heart rate and breathing.2014

    • Author(s)
      Yamauchi M, Jacono FJ, Fujita Y, Kumamoto M, Yoshikawa M, Campanaro CK, Loparo KA, Strohl KP, Kimura H.
    • Journal Title

      Sleep Breath

      Volume: 18 Issue: 4 Pages: 829-835

    • DOI

      10.1007/s11325-014-0951-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The impact of obstructive sleep apnea and nasal CPAP on circulating adiponectin levels2014

    • Author(s)
      Yoshikawa M, Yamauchi M, Fujita Y, Koyama N, Fukuoka A, Tamaki S, Yamamoto Y, Tomoda K, Kimura H
    • Journal Title

      Lung

      Volume: 192(2) Issue: 2 Pages: 289-295

    • DOI

      10.1007/s00408-013-9550-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Evaluations of the Patient2014

    • Author(s)
      Ramsey R, Khanna A, Yamauchi M.
    • Journal Title

      Competencies in Sleep Medicine

      Volume: 1 Pages: 109-127

    • DOI

      10.1007/978-1-4614-9065-4_7

    • ISBN
      9781461490647, 9781461490654
    • Related Report
      2014 Research-status Report
  • [Journal Article] Keep the airway open and let the brain sleep.2014

    • Author(s)
      Decker M, Yamauchi M, Strohl KP.
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 190 Issue: 11 Pages: 1207-1209

    • DOI

      10.1164/rccm.201410-1939ed

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Breathing irregularity during wakefulness associates with CPAP acceptance in sleep apnea.2013

    • Author(s)
      Yamauchi M, Jacono FJ, Fujita Y, Yoshikawa M, Ohnishi Y, Nakano H, Campanaro CK, Loparo KA, Strohl KP, Kimura H.
    • Journal Title

      Sleep Breath

      Volume: 17 Issue: 2 Pages: 845-852

    • DOI

      10.1007/s11325-012-0775-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] OSAS Phenotypes and Breathing Irregularity - Road Ahead to Personalized Therapy -2015

    • Author(s)
      Motoo Yamauchi
    • Organizer
      Beijing International Sleep Medicine Forum 2015
    • Place of Presentation
      Beijing, China
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多系統萎縮症 -睡眠障害と突然死へのアプローチ- 呼吸器内科の立場から(睡眠呼吸障害とその病態)2015

    • Author(s)
      山内基雄
    • Organizer
      日本睡眠学会第40回定期学術集会
    • Place of Presentation
      宇都宮
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 睡眠検査に関するワーキンググループ(PSG、携帯型装置、MWT)のエキスパートコンセンサス(案)報告 -睡眠呼吸障害におけるPSG の適応-2015

    • Author(s)
      山内基雄
    • Organizer
      日本睡眠学会第40回定期学術集会
    • Place of Presentation
      宇都宮
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Chronic Effects of Ramelteon On Sleep Disordered Breathing In Patients with OSA And Insomnia: A Preliminary Study2015

    • Author(s)
      Motoo Yamauchi, Makiko Kumamoto, Yukio Fujita, Hiroki Uyama, Noriko Koyama, Masanori Yoshikawa, Hiroshi Kimura
    • Organizer
      SLEEP 2015
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 閉塞型睡眠時無呼吸症候群治療の現状と今後の展開-Interdisciplinary treatment approachのなかでの歯科補綴の役割-2015

    • Author(s)
      山内基雄
    • Organizer
      日本補綴歯科学会第124回学術大会
    • Place of Presentation
      さいたま市
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Proportion of Accompanying Arousal to Apneic Event Affects Systemic Blood Pressure but not Sympathetic Nerve Activity2015

    • Author(s)
      Motoo Yamauchi, Yukio Fujita, Hiroki Uyama, Makiko Kumamoto, Noriko Koyama, Masanori Yoshikawa, Hiroshi Kimura
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Breathing Irregularity during Wakefulness as a Predictive Factor for CPAP Acceptance2015

    • Author(s)
      Motoo Yamauchi
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Systemic Effects of Intermittent Hypoxia in OSA. In Presidential Symposium -Cross-talk between respiration and circulation in sleep apnea-2015

    • Author(s)
      Motoo Yamauchi, Hiroshi Kimura
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 無呼吸低呼吸イベントに伴うArousalが高血圧に及ぼす影響について2014

    • Author(s)
      山内基雄、藤田幸男、熊本牧子、鵜山広樹、児山紀子、吉川雅則、木村 弘.
    • Organizer
      第24回日本呼吸ケア・リハビリテーション学会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] OSASの個別化医療に向けた症型分類2014

    • Author(s)
      山内基雄
    • Organizer
      日本睡眠学会第39回定期学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] The Proportion of Accompanying Arousal to Apneic Event Affects Systemic Blood Pressure but not Sympathetic Nerve Activity.2014

    • Author(s)
      Motoo Yamauchi, Yukio Fujita, Masanori Yoshikawa, Hiroshi Kimura.
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Ventilatory Decrease during Transition from Wakefulness to Sleep Associates with AHI in NREM Sleep.2014

    • Author(s)
      Motoo Yamauchi, Yukio Fujita, Makiko Kumamoto, Masanori Yoshikawa, Hiroshi Kimura.
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] The Differences between Individuals in the Decrease of Ventilation during the Transition from Wakefulness to Sleep Associates with the Difference in Apnea-Hypopnea Indices between NREM and REM Sleep.2013

    • Author(s)
      Motoo Yamauchi, Yukio Fujita, Masanori Yoshikawa, Hiroshi Kimura.
    • Organizer
      American Thoracic Society International Conference 2013
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 覚醒から入眠に伴う換気量変化と睡眠呼吸障害イベント分布との関連について2013

    • Author(s)
      山内基雄、藤田幸男、熊本牧子、吉川雅則、大西徳信、中野 博、木村 弘.
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] OSASのPhenotypingと個別化治療の構築に向けて2013

    • Author(s)
      山内基雄、木村 弘.
    • Organizer
      第50回日本臨床生理学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] SAS up-to-date 発症メカニズム2015

    • Author(s)
      山内基雄
    • Total Pages
      92
    • Publisher
      科学評論社
    • Related Report
      2015 Annual Research Report
  • [Book] 臨床睡眠検査マニュアル2015

    • Author(s)
      山内基雄
    • Total Pages
      247
    • Publisher
      ライフ・サイエンス
    • Related Report
      2015 Annual Research Report
  • [Book] 新・呼吸器専門医テキスト2015

    • Author(s)
      山内基雄
    • Total Pages
      598
    • Publisher
      南江堂
    • Related Report
      2015 Annual Research Report
  • [Book] 睡眠障害 知る 診る 治す2014

    • Author(s)
      山内基雄
    • Total Pages
      203
    • Publisher
      メジカルビュー社
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2023-03-16  

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